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Table 4 The specific chemotherapeutic agents and premedications implicated in clinically significant Drug-drug interactions among cancer patients, Uganda

From: Frequency, severity, and factors associated with clinically significant drug-drug interactions among patients with cancer attending Mbarara Regional Referral Hospital Cancer Unit, Uganda

Drug

Frequency

Percentage (%)

N = 495

Chemotherapeutic agents

 Doxorubicin

33

6.7

 Cyclophosphamide

33

6.7

 Methotrexate

30

6.1

 Paclitaxel

21

4.2

 Fluorouracil

17

3.4

 Capecitabine

17

3.4

 Docetaxel

13

2.6

 Mercaptopurine

12

2.4

 Thalidomide

9

1.8

 Oxaliplatin

7

1.4

 Cisplatin

7

1.4

 Carboplatin

5

0.8

 Goserelin

5

0.8

 Imatinib

4

0.8

 Erlotinib

4

0.8

 Bortezomib

3

0.6

 Bicalutamide

1

0.2

Premedicationsa/Other drugs

 Morphine

103

21

 Metoclopramide

92

19

 Dexamethasone

54

11

 Ondansetron

51

10

 Fosaprepitant

11

2.2

  1. aThe administered drugs minutes to hours before cancer chemotherapy to prevent adverse events such as hypersensitivity or nausea and vomiting due to cancer chemotherapy