Table 5 Enriched molecular functions in hypomethylated regions between HCC and NASH

CD HCC vs. NASH

DNA-binding transcription activator activity, RNA polymerase II-specific

2.14

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1.82

Protein binding

1.17

CS HCC vs. NASH

Wnt-protein binding

4.20

Frizzled binding

3.17

DNA-binding transcription activator activity, RNA polymerase II-specific

2.21

DNA-binding transcription repressor activity, RNA polymerase II-specific

2.07

RNA polymerase II cis-regulatory region sequence-specific DNA binding

2.00

Receptor ligand activity

1.52

Cation binding

1.18