Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma

Table 3 Top 10 hypermethylated and hypomethylated regions between choline deficient HCC and choline supplemented HCC

	Chromosome	Start	End	Q-value	Methylation difference (%)	Gene	CpG Category	Gene Structure
Hypermethylation	Chr 7	27658325	27658325	5.06E-41	68.16218	TTC9B	Island	Exon
	Chr 5	110363759	110363759	1.58E-41	57.24965	LCROL1	Island	Exon
	Chr 1	42741736	42741736	1.39E-86	56.99229	LOC108167622	Other	Intron
	Chr 16	4078449	4078449	8.78E-54	55.9661	TRAP1	Shore	–
	Chr 7	107210287	107210287	4.31E-25	54.50725	RBMXL2	Island	Exon
	Chr 9	107669835	107669835	3.47E-63	54.2572	SLC38A3	Other	Intron
	Chr 19	8679239	8679239	1.30E-35	54.08986	CHRM1	Other	Exon
	Chr 4	120124981	120124981	7.45E-29	54.015	EDN2	Other	Exon
	Chr 7	107210301	107210301	1.45E-24	53.93071	RBMXL2	Island	Exon
	Chr 1	190139252	190139252	8.04E-63	53.61003	PROX1	Other	Intron
Hypomethylation	Chr 9	121076534	121076534	2.87E-43	−66.7969	OLFR843	Other	Intron
	Chr 7	27257369	27257369	6.56E-67	−62.1354	NUMBL	Shore	Exon
	Chr 10	76634403	76634403	3.22E-65	−61.6133	–	Other	Intron
	Chr 4	45785050	45785050	1.68E-54	−60.7105	ALDH1B1	Other	–
	Chr 10	76584578	76584578	4.26E-46	−59.9492	FTCD	Other	Exon
	Chr 12	74283740	74283740	5.55E-38	−59.9486	FASTKD2	Shore	Intron
	Chr 10	73300112	73300112	2.99E-43	−59.8009	FAM96A	Other	Intron
	Chr 9	46986808	46986808	1.95E-46	−59.3403	GM4791	Other	–
	Chr 2	44162442	44162442	5.78E-45	−59.2628	ARHGAP15	Other	Intron
	Chr 7	37356388	37356388	3.96E-45	−58.4701	–	Other	–

ISSN: 1471-2407