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Table 2 Top 10 hypermethylated and hypomethylated regions between HCC and NASH in the choline supplemented model

From: Differential methylation patterns in lean and obese non-alcoholic steatohepatitis-associated hepatocellular carcinoma

 

Chromosome

Start

End

Q-value

Methylation difference (%)

Gene

CpG Category

Gene Structure

Hypermethylation

Chr 10

31860051

31860051

5.08E-36

100

RNF217

Other

Intron

 

Chr 3

96919939

96919939

6.65E-59

98

GJA8

Other

Exon

 

Chr 17

54643532

54643532

2.75E-37

97.71429

Gm32055

Other

–

 

Chr 1

21988549

21988549

3.91E-54

96.51515

KCNQ5

Other

Intron

 

Chr 5

142385284

142385284

2.78E-42

95.35104

PTPRE

Other

–

 

Chr 2

123549054

123549054

1.02E-29

95.26627

MORN3

Other

–

 

Chr 3

55348282

55348282

1.08E-31

93.17359

Gm40051

Other

Intron

 

Chr 13

51672327

51672327

5.01E-42

91.07143

SECISBP2

Other

Intron

 

Chr X

60093579

60093579

4.50E-29

90.47619

MCF2

Other

Intron

 

Chr 16

29868324

29868324

8.94E-38

89.09953

RNF123

Other

–

Hypomethylation

Chr 5

36228842

36228842

1.50E-57

−87.4512

PSAPL1

Other

Intron

 

Chr 4

98726981

98726981

1.18E-39

−87.4396

L1TD1

Other

Intron

 

Chr 4

82537544

82537544

7.33E-64

−87.2659

–

Other

Intron

 

Chr 7

108951080

108951080

1.18E-26

−86.2069

Gm39067

Island

Intron

 

Chr 11

82930668

82930668

8.16E-37

−86.1035

UNC45BOS

Shore

Exon

 

Chr 5

128527390

128527390

1.68E-27

−85.9649

–

Other

–

 

Chr 5

105759229

105759229

1.97E-27

−84.8837

LRRC8D

Other

Intron

 

Chr 12

25240371

25240371

6.01E-20

−84.3137

–

Other

Intron

 

Chr 2

172863024

172863024

6.24E-28

−83.871

–

Other

Intron

 

Chr 12

36317937

36317937

8.35E-39

−83.8572

SOSTDC1

Shore

Exon

  1. Abbreviation: Chr Chromosome