Table 2 Notch signaling genes are differentially expressed across different breast cancer intrinsic subtypes
Genes | subtypes | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | Basal/Claudin-low Vs. HER2 | Basal/Claudin-low Vs. Luminal A | Basal/Claudin-low Vs. Luminal B | Basal/Claudin-low Vs. Normal | HER2 Vs. Luminal A | HER2 Vs. Luminal B | HER2 Vs. Normal | Luminal A Vs. Luminal B | Luminal A Vs. Normal | Luminal B Vs. Normal |
NOTCH-1 | 0.5705 | 0.7185 | 0.8889 | 0.4662 | 0.1481 | 0.3185 | -0.1043 | 0.1704 | -0.2523 | -0.4227 |
NOTCH-2 | 0.1703 | 0.05276 | 0.176 | 0.08958 | -0.1176 | 0.00567 | -0.08076 | 0.1233 | 0.03683 | -0.08643 |
NOTCH-3 | -0.06546 | 0.07726 | 0.3458 | 0.002168 | 0.1427 | 0.4112 | 0.06763 | 0.2685 | -0.07509 | -0.3436 |
JAG1 | 0.2552 | -0.08598 | 0.2793 | -0.2756 | -0.3411 | 0.02411 | -0.5307 | 0.3653 | -0.1896 | -0.5549 |
DLL1 | 0.1577 | 0.01206 | 0.3112 | -0.2711 | -0.1456 | 0.1535 | -0.4288 | 0.2991 | -0.2831 | -0.5823 |
LFNG | -1.085 | -1.028 | -0.9328 | -0.8226 | 0.057 | 0.152 | 0.2623 | 0.09504 | 0.2053 | 0.1103 |
ST3GAL6 | 0.4489 | 0.3943 | 0.4532 | 0.3689 | -0.05451 | 0.004347 | -0.07997 | 0.05886 | -0.02546 | -0.08432 |
FBXW11 | 0.09856 | -0.1418 | -0.2242 | -0.06036 | -0.2404 | -0.3228 | -0.1589 | -0.08242 | 0.08147 | 0.1639 |
DTX1 | 0.004355 | 0.05787 | 0.1372 | -0.02928 | 0.05351 | 0.1329 | -0.03363 | 0.07934 | -0.08715 | -0.1665 |
DTX2 | -0.241 | 0.2525 | 0.4197 | 0.1062 | 0.4935 | 0.6607 | 0.3471 | 0.1671 | -0.1464 | -0.3135 |
DTX4 | -0.00222 | 0.05364 | 0.04568 | 0.007635 | 0.05585 | 0.0479 | 0.009852 | -0.00796 | -0.046 | -0.03804 |
CUL1 | 0.1253 | 0.2535 | 0.2479 | 0.3081 | 0.1282 | 0.1226 | 0.1828 | -0.00563 | 0.05461 | 0.06023 |
ARRB1 | -0.2722 | -0.6297 | -0.5054 | -0.6481 | -0.3575 | -0.2332 | -0.3759 | 0.1243 | -0.01845 | -0.1427 |
SKP1 | -0.297 | -0.8474 | -0.9083 | -0.6829 | -0.5504 | -0.6113 | -0.3859 | -0.06089 | 0.1645 | 0.2254 |
RBX1 | 0.1089 | 0.142 | -0.06428 | 0.1985 | 0.03308 | -0.1732 | 0.0896 | -0.2062 | 0.05653 | 0.2628 |
KAT2A | 0.003187 | -0.1908 | -0.2121 | -0.1482 | -0.194 | -0.2153 | -0.1514 | -0.02132 | 0.04258 | 0.0639 |
MAML2 | 0.19 | 0.1819 | 0.2092 | 0.0813 | -0.00809 | 0.01912 | -0.1087 | 0.02721 | -0.1006 | -0.1279 |
PPARD | -0.02952 | 0.2491 | 0.2538 | 0.2128 | 0.2786 | 0.2833 | 0.2423 | 0.004739 | -0.03626 | -0.041 |
TCF7L2 | 0.1925 | 0.177 | 0.4829 | -0.07302 | -0.01549 | 0.2904 | -0.2655 | 0.3059 | -0.25 | -0.556 |
PSENEN | -0.2161 | -0.1927 | -0.3158 | 0.04409 | 0.02336 | -0.09966 | 0.2602 | -0.123 | 0.2368 | 0.3599 |
PSEN2 | -0.2381 | -0.3918 | -0.4069 | -0.09983 | -0.1536 | -0.1687 | 0.1383 | -0.01507 | 0.2919 | 0.307 |
APH1A | -0.04979 | 0.04075 | -0.08864 | 0.2834 | 0.09054 | -0.03885 | 0.3332 | -0.1294 | 0.2426 | 0.372 |
PRKCA | 0.6862 | 0.6888 | 0.8771 | 0.419 | 0.002588 | 0.1909 | -0.2672 | 0.1883 | -0.2698 | -0.4582 |
SAP30 | 0.2507 | 0.3426 | 0.02529 | 0.5152 | 0.09191 | -0.2254 | 0.2645 | -0.3173 | 0.1726 | 0.4899 |
HEY1 | -0.1247 | -0.4304 | -0.0336 | -0.3869 | -0.3057 | 0.09106 | -0.2623 | 0.3968 | 0.04341 | -0.3533 |
HES1 | -0.2678 | -0.3541 | -0.1644 | -0.4587 | -0.08628 | 0.1034 | -0.1909 | 0.1896 | -0.1046 | -0.2942 |
CCND1 | -0.5467 | -1.177 | -1.449 | -0.8084 | -0.6308 | -0.9024 | -0.2617 | -0.2717 | 0.369 | 0.6407 |
WNT2 | -0.00594 | 0.2019 | 0.1701 | 0.3056 | 0.2079 | 0.176 | 0.3116 | -0.03185 | 0.1037 | 0.1356 |
WNT5A | -0.05577 | -0.4741 | -0.08401 | -0.2964 | -0.4183 | -0.02823 | -0.2406 | 0.3901 | 0.1777 | -0.2123 |
FZD1 | 0.2265 | 0.03646 | 0.1508 | -0.05784 | -0.1901 | -0.07575 | -0.2844 | 0.1143 | -0.09431 | -0.2086 |
FZD5 | 0.07263 | 0.1354 | 0.1105 | 0.1065 | 0.06279 | 0.03789 | 0.03388 | -0.02489 | -0.02891 | -0.00401 |
FZD7 | 0.9775 | 0.6828 | 1.074 | 0.06305 | -0.2947 | 0.09693 | -0.9144 | 0.3916 | -0.6197 | -1.011 |