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Table 1 Notch signaling genes are differentially expressed across different breast cancer intrinsic subtypes

From: Notch signaling pathway: a comprehensive prognostic and gene expression profile analysis in breast cancer

Genes

subtypes

         
 

Basal/Claudin-low

Vs. HER2

Basal/Claudin-low

Vs. Luminal A

Basal/Claudin-low

Vs. Luminal B

Basal/Claudin-low

Vs. Normal

HER2 Vs. Luminal A

HER2 Vs. Luminal B

HER2 Vs. Normal

Luminal A Vs. Luminal B

Luminal A Vs. Normal

Luminal B Vs. Normal

NOTCH-1

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0239

 < 0.0001

 < 0.0001

 < 0.0001

NOTCH-2

 < 0.0001

0.0280

 < 0.0001

0.0290

 < 0.0001

0.8522

0.0410

0.0410

0.2445

0.0139

NOTCH-3

0.2749

0.0535

 < 0.0001

0.9757

0.0008

 < 0.0001

0.2773

 < 0.0001

0.1330

 < 0.0001

JAG1

 < 0.0001

0.0208

 < 0.0001

 < 0.0001

 < 0.0001

0.5840

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

DLL1

0.0008

0.7272

 < 0.0001

 < 0.0001

0.0002

0.0003

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

LFNG

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.4220

0.0726

0.0125

0.0897

0.0094

0.2392

ST3GAL6

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0376

0.8781

0.0260

0.0046

0.4143

0.0116

FBXW11

0.0163

 < 0.0001

 < 0.0001

0.1405

 < 0.0001

 < 0.0001

0.0042

 < 0.0001

0.0094

 < 0.0001

DTX1

0.8746

0.0003

 < 0.0001

0.3039

0.0076

 < 0.0001

0.3279

 < 0.0001

 < 0.0001

 < 0.0001

DTX2

 < 0.0001

 < 0.0001

 < 0.0001

0.0772

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0013

 < 0.0001

DTX4

0.8560

 < 0.0001

 < 0.0001

0.5745

 < 0.0001

 < 0.0001

0.5069

0.2852

 < 0.0001

0.0009

CUL1

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.7459

0.0227

0.0375

ARRB1

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0015

 < 0.0001

0.0176

0.7954

0.1000

SKP1

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0168

 < 0.0001

 < 0.0001

RBX1

 < 0.0001

0.0794

0.0168

 < 0.0001

 < 0.0001

0.4207

0.2319

0.0002

 < 0.0001

0.1287

KAT2A

0.9532

 < 0.0001

 < 0.0001

0.0070

 < 0.0001

0.0001

0.0430

0.5435

0.4026

0.2728

MAML2

 < 0.0001

 < 0.0001

 < 0.0001

0.0005

0.4603

0.0992

 < 0.0001

0.0011

 < 0.0001

 < 0.0001

PPARD

0.3814

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.7865

0.1813

0.1579

TCF7L2

 < 0.0001

 < 0.0001

 < 0.0001

0.1177

0.6095

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

PSENEN

 < 0.0001

 < 0.0001

 < 0.0001

0.2374

 < 0.0001

0.3534

 < 0.0001

0.0007

 < 0.0001

 < 0.0001

PSEN2

 < 0.0001

 < 0.0001

 < 0.0001

0.0234

0.5739

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0061

APH1A

0.3314

0.2413

0.0303

 < 0.0001

0.0256

0.4093

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

PRKCα

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.9256

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

SAP30

 < 0.0001

0.6201

0.0001

 < 0.0001

 < 0.0001

0.0773

0.0030

0.0002

 < 0.0001

0.0007

HEY1

0.0321

 < 0.0001

0.4648

 < 0.0001

 < 0.0001

0.0816

0.0001

 < 0.0001

0.4229

 < 0.0001

HES1

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0354

0.0262

0.0004

 < 0.0001

0.0325

 < 0.0001

CCND1

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0177

 < 0.0001

 < 0.0001

 < 0.0001

WNT2

0.8885

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.2228

0.0057

0.0024

WNT5A

0.2470

 < 0.0001

0.0449

 < 0.0001

 < 0.0001

0.5831

0.0001

 < 0.0001

0.0065

0.0005

FZD1

 < 0.0001

0.2190

 < 0.0001

0.2373

 < 0.0001

0.0351

 < 0.0001

 < 0.0001

0.0269

 < 0.0001

FZD5

0.0003

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0028

0.0543

0.0056

0.0383

0.7824

FZD7

 < 0.0001

 < 0.0001

 < 0.0001

0.4576

 < 0.0001

0.0500

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

  1. Representative statistics (p-values) are from RNA-Seq data for genes involved in Notch signaling from METABRIC by Pam50 gene expression subtype classification. Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test. Statistically significant values of *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 were determined