Fig. 6

Notch signaling pathway is positively correlated with tumor-evasion, metastasis and angiogenesis markers. Co-expression (mRNA) correlation analysis between Notch pathway elements and tumor-evasion, metastasis and angiogenesis markers using a, LIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK b, GILDEA_METASTASIS, and (c), HU_ANGIOGENESIS_UP gene sets, respectively (https://www.gsea-msigdb.org/gsea/msigdb). Correlation heatmap (Pearson r) of the transcriptomes from METABRIC breast cancer project samples (n = 1986). The red color refers to negative correlation, and the blue color indicates positive correlation. Immune-evasion-related genes (genes up-regulated in highly immune-resistant cancer cells) comprised 20 genes. The metastasis-related genes comprised 29 genes. The angiogenesis-related genes contained 21 genes. The mRNA expression data were extracted from METABRIC. Pearson's correlation analysis was used for the analysis of co-expression between genes