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Table 4 Multivariate analysis for EFS and OS among MLL-r positive ALL patients

From: Prognostic value and outcome for acute lymphocytic leukemia in children with MLL rearrangement: a case-control study

Outcome

Variable

HR (95% CI)

P value

EFS

T-cell

5.0 (1.5, 17.5)

0.011

WBC ≥50 × 109/L

6.4 (1.6, 24.8)

0.007

MLL-AF4

3.5 (1.1, 11.5)

0.035

MLL-PTD

2.4 (0.6, 9.9)

0.223

MLL-ENL

1.9 (0.2, 15.4)

0.554

MLL-others

1.5 (0.2, 12.6)

0.682

PPR

6.1 (0.2, 212.8)

0.321

D15 BM NR

3.6 (0.5, 26.3)

0.214

D33 BM NR

1.4 (0.3, 6.3)

0.653

D15 MRD (+)

4.8 (1.4, 17.1)

0.015

D33 MRD (+)

0.1 (0.0, 353.7)

0.596

SCT

0.4(0.0, 0.9)

0.027

OS

T-cell

6.7 (1.5–29.6)

0.012

WBC ≥50 × 109/L

3.6 (1.1, 12.4)

0.041

MLL-AF4

4.6 (1.5, 14.4)

0.008

MLL-PTD

4.5 (0.3, 57.0)

0.251

MLL-ENL

0.9 (0.7, 1.3)

0.700

MLL-others

2.6 (0.8, 8.3)

0.115

PPR

6.9 (0.1, 616.6)

0.402

D15 BM NR

0.3 (0.1, 1.6)

0.180

D33 BM NR

6.9 (0.1, 616.6)

0.402

D15 MRD (+)

2.6 (1.1, 6.0)

0.025

D33 MRD (+)

3.1 (0.2, 40.8)

0.384

SCT

0.2 (0.0, 1.1)

0.065

  1. Abbreviation: WBC white blood cell, Hb haemoglobin, PLT platelet, CNS L central nervous system leukemia, SR standard risk, IR intermediate risk, HR high risk, PGR prednisone good response, PPR prednisone poor response, MRD minimal residual disease evaluation, BM bone marrow, SCT stem cell transplantation