Table 1 Univariate and multivariate analyses of RFS and OS rates for 218 HCC patients after curative resection
RFS | OS | |||||
|---|---|---|---|---|---|---|
Variables | UnivariateP | Multivariable Analysis | UnivariateP | Multivariable Analysis | ||
HR (95% CI) | P | HR (95% CI) | P | |||
Sex | ||||||
  Female | ||||||
  Male | 0.789 |  |  | 0.816 |  |  |
Age (y) | ||||||
   ≤ 50 | ||||||
   > 50 | 0.213 |  |  | 0.210 |  |  |
HBsAg | ||||||
  Negative | ||||||
  Positive | 0.023 | 2.299 (1.035–5.108) | 0.041 | 0.137 |  |  |
Child–Pugh classificationl | ||||||
  A | ||||||
  B | 0.022 | 2.164 (0.512–9.143) | 0.294 | 0.230 |  |  |
AFP (ng/ml) | ||||||
   ≤ 20 | ||||||
  20–400 | ||||||
   > 400 | 0.824 |  |  | 0.509 |  |  |
GGT (units/L) | ||||||
   ≤ 50 | ||||||
   > 50 | 0.216 |  |  | 0.104 |  |  |
Tumor size (cm) | ||||||
   ≤ 5 | ||||||
   > 5 | 0.001 | 1.598 (1.005–2.542) | 0.048 | 0.006 | 1.523 (0.958–2.421) | 0.075 |
Satellite nodules | ||||||
  No | ||||||
  Yes | 0.002 | 1.820 (0.928–3.569) | 0.081 | 0.001 | 1.862 (0.954–3.633) | 0.068 |
Tumor capsule | ||||||
  No | ||||||
  Yes | 0.196 |  |  | 0.688 |  |  |
Vascular invasion | ||||||
  No | ||||||
  Yes | 0.933 |  |  | 0.066 |  |  |
Cirrhosis | ||||||
  No | ||||||
  Yes | 0.308 |  |  | 0.988 |  |  |
TNM classification2 | ||||||
  I/II | ||||||
  III/IV | 0.037 | 1.357 (0.692–2.663) | 0.374 | 0.001 | 1.382 (0.707–2.702) | 0.344 |
(Continued) | ||||||
DRD3 expression | ||||||
  Negative | ||||||
  Positive | 0.048 | 0.469 (0.299–0.735) | 0.001 | 0.001 | 0.502 (0.321–0.785) | 0.003 |