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Fig. 4 | BMC Cancer

Fig. 4

From: Dopamine receptor D3 is related to prognosis in human hepatocellular carcinoma and inhibits tumor growth

Fig. 4

DRD3 plays a crucial role in HCC cell proliferation, migration and invasion in vitro. (A, B) CCK8 and colony formation assays demonstrated that upregulation of DRD3 expression significantly inhibited cell proliferation, and also suppressed the migration and invasion in HCC cells according to the Transwell assays and wound healing assays (E, F). (C, D, G, H) Downregulation of DRD3 expression promoted cell proliferation, migration and invasion. (I) PD128907 significantly suppressed cell proliferation at 10 nM and 100 nM. U99194 stimulated cell proliferation at 1 nM. (J) Colony number was decreased with PD128907 treating in HCC cells, and was increased with U99194 treating. (K, L) PD128907 (100 nM) inhibited migration and invasion in HCC cell lines, while U99194 (1 nM) promoted migration and invasion. * P < 0.05, ** P < 0.01, *** P < 0.001

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