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Fig. 3 | BMC Cancer

Fig. 3

From: TG2 as a novel breast cancer prognostic marker promotes cell proliferation and glycolysis by activating the MEK/ERK/LDH pathway

Fig. 3

TG2 regulated glycolysis via controlling MEK/ERK/LDH pathway. A GSEA analysis shown that KRAS pathway enriched. B p-MEK, p-ERK, LDHA and LDHB was down-regulated in TG2 knockdown cell line (SK-BR-3), while upregulated in TG2 overexpression cell line (BT-474) by western blot. C and E The mRNA level of LDHA and LDHB was detected by RT-qPCR in TG2 knockdown and overexpression cell lines. D and F The consumption of glucose and production of lactate was measured in TG2 knockdown and overexpression cell lines. (* p<0.05, ** p<0.01)

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BMC Cancer

ISSN: 1471-2407

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