Table 4 MDSCs levels (cells/µL) according to tumor response
MDSCs | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | M-MDSCs | G-MDSCs | ||||||||||
CB (SD ≥ 24 weeks) (n = 7) | PD (n = 12) | CB (SD ≥ 24 weeks) (n = 7) | PD (n = 12) | CB (SD ≥ 24 weeks) (n = 7) | PD (n = 12) | |||||||
Median | IR | Median | IR | Median | IR | Median | IR | Median | IR | Median | IR | |
Baseline | 38.6 (n = 7) | 53.0 | 47.6 (n = 11) | 42.8 | 30.7 (n = 7) | 32.8 | 39.8 (n = 11) | 33.2 | 7.9 (n = 7) | 20.9 | 5.2 (n = 11) | 27.9 |
C3 | 17.4 (n = 7) | 27.0 | 60.7 (n = 11) | 247.4 | 4.3 (n = 7) | 13.9 | 47.4 (n = 11) | 223.1 | 5.2 (n = 7) | 10.3 | 7.7 (n = 11) | 24.3 |
C6/EOT | 12.4 (n = 7) | 8.5 | 23.2 (n = 5) | 37.2 | 6.3 (n = 7) | 8.5 | 8.0 (n = 5) | 31.2 | 4.3 (n = 7) | 10.2 | 12.4 (n = 5) | 8.6 |
Baseline vs. C6/EOT p-value | 0.0781 | 0.8750 | 0.0469 | 0.8750 | 0.6875 | 0.6250 | ||||||
Baseline vs. C3 p-value | 0.2969 | 0.6953 | 0.0313 | 0.7695 | 0.9375 | 0.6250 | ||||||
CB vs. PD (C6/EOT) p-value | 0.0513 | 0.7453 | 0.0348 | |||||||||
CB vs. PD (C3) p-value | 0.1743 | 0.0572 | 0.5261 | |||||||||
CB vs. PD (baseline) p-value | 0.3651 | 0.1743 | 0.9278 | |||||||||