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Table 2 Predictors of adherence

From: Predictors of adherence and the role of primary non-adherence in antihormonal treatment of breast cancer

Characteristics

OR (95% CI)

P-value

OR (95% CI)

P-value

 

Unadjusted

Adjusted for age

Age at diagnosis

  < 40

0.4 (0.2-0.7)

0.001

  

 40-49

1.3 (0.8-2.0)

0.306

  

 50-59

Ref

   

 60-69

0.8 (0.6-1.2)

0.230

  

 70-79

0.7 (0.5-1.2)

0.203

  

  ≥ 80

0.2 (0.1-0.4)

< 0.001

  

Tumour stage

 T1

Ref

 

Ref

 

 T2

1.2 (0.9-1.6)

0.258

1.5 (1.1-2.1)

0.011

 T3-T4

2.5 (0.8-7.1)

0.098

3.7 (1.2-11.2)

0.023

 Unknown

1.2 (0.8-2.0)

0.368

1.3 (0.8-2.1)

0.286

Histopathological type

 Ductal

Ref

 

Ref

 

 Lobular

1.3 (0.8-2.0)

0.256

1.3 (0.9-2.1)

0.188

 Other

0.8 (0.5-1.4)

0.454

1.0 (0.6-1.6)

0.915

 Unknown

0.8 (0.2-4.2)

0.803

1.0 (0.2-5.8)

0.964

Histological grade

 Grade 1

Ref

 

Ref

 

 Grade 2

1.0 (0.7-1.7)

0.858

1.0 (0.6-1.6)

0.992

 Grade 3

1.5 (0.9-2.5)

0.124

1.6 (0.9-2.7)

0.108

 Unknown

1.3 (0.7-2.4)

0.417

1.2 (0.6-2.3)

0.550

Axillary lymph node metastasis

 0

Ref

 

Ref

 

 1-3

2.1 (1.5-3.0)

< 0.001

2.2 (1.6-3.1)

< 0.001

  ≥ 4

2.0 (1.3-3.2)

0.004

2.1 (1.3-3.4)

0.002

 Unknown

0.7 (0.4-1.2)

0.175

1.3 (0.7-2.6)

0.415

Neoadjuvant treatment

 No

Ref

 

Ref

 

 Yes

1.3 (0.9-1.9)

0.220

1.4 (0.9-2.1)

0.098

Type of antihormonal treatment

 Tamoxifen only

Ref

 

Ref

 

 Tamoxifen ➔ AI

2.4 (1.6-3.7)

< 0.001

1.6 (1.0-2.6)

0.034

 AI only

2.0 (1.3-3.0)

0.001

1.5 (0.9-2.4)

0.099

 AI ➔ Tamoxifen

1.9 (1.1-3.4)

0.031

1.3 (0.7-2.4)

0.484

 More than one switch

2.0 (1.0-4.0)

0.060

1.3 (0.6-2.8)

0.437

 No antihormonal treatment registered

0

0.996

0

0.995

Switch at two years

 Noa

Ref

 

Ref

 

 Yes

1.7 (1.0-2.8)

0.033

1.5 (0.9-2.4)

0.141

 Monotherapy

0.9 (0.6-1.3)

0.473

1.0 (0.7-1.5)

0.988

 No antihormonal treatment registered

0

0.995

0

0.995

Radiation therapy

 No

Ref

 

Ref

 

 Yes

1.8 (1.3-2.4)

< 0.001

1.2 (0.9-1.7)

0.209

Chemotherapy

 No

Ref

 

Ref

 

 Yes

3.0 (2.2-3.9)

< 0.001

3.8 (2.6-5.5)

< 0.001

  1. aSwitch at some other point in time (+/− 6 months)