Genetic variant in miR-17-92 cluster binding sites is associated with esophageal squamous cell carcinoma risk in Chinese population

Table 4 GMDR analysis for the best SNP-SNP and SNP-smoking interaction models

No. of loci	Best combination	Te-BA	Sign test (P)	CVC
SNP-SNP interaction^a
2	rs12594531, rs1366600	0.512	7 (0.172)	6/10
3	rs1804506, rs3741779, rs3763763	0.538	8 (0.055)	8/10
4	rs1366600, rs1804506, rs3741779, rs3763763	0.558	9 (0.011)	9/10
5	rs12594531, rs1366600, rs1804506, rs3741779, rs3763763	0.538	7 (0.172)	10/10
SNP-smoking interaction^b
2	smoking, rs1366600	0.574	9 (0.011)	8/10
3	smoking, rs12594531, rs1366600	0.525	7 (0.172)	4/10
4	smoking, rs12594531, rs1366600, rs1804506	0.538	9 (0.011)	5/10
5	smoking, rs1366600, rs1804506, rs3741779, rs3763763	0.526	6 (0.377)	4/10
6	smoking, rs12594531, rs1366600, rs1804506, rs3741779, rs3763763	0.552	8 (0.055)	10/10

^aadjusted for age, gender, smoking status and family history of cancers
^badjusted for age, gender and family history of cancers
GMDR Generalized multifactor dimensionality reduction, Te-BA Testing-balanced accuracy, CVC Cross-validation consistency

ISSN: 1471-2407