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Table 3 Univariate analysis of prognostic factors for progression-free and overall survival in 21 rheumatoid arthritis patients with other iatrogenic immunodeficiency-associated (OIIA) T- and NK-cell lymphoproliferative disorders

From: Clinicopathological findings, prognosis, and Epstein–Barr virus infection in rheumatoid arthritis patients with other iatrogenic immunodeficiency-associated T- and NK-cell lymphoproliferative disorders

Risk factors

Univariate analysis of

Univariate analysis of

progression free survival

 

overall survival

 

Hazard ratio

p-value

Hazard ratio

p-value

Age ≥ 70 years

2.771

0.301

2.225

0.481

LDH ≥ 500 U/L

3.919

0.038

3.849

0.037

sIL2R ≥ 2000 U/ml

2.367

0.135

3.497

0.079

Stages III and IV

1.309

0.474

2.474

0.25

Large atypical lymphocytes

5.808

0.01

6.052

0.008

CD30 ≥ 30%

3.173

0.054

3.982

0.034

TFH phenotype

0.964

0.685

0.642

0.423

p53 ≥ 50%

7.114

0.003

7.007

0.003

CMYC ≥ 50%

5.487

0.009

5.682

0.006

PD-L1 n+

3.022

0.076

3.501

0.057

PD-L1 n+ and R3+

2.087

0.257

1.395

0.519

EBER+ atypical lymphocytes ≥ 50%

3.173

0.054

3.439

0.043

TCRγ gene clonality

2.629

0.175

4.962

0.086

  1. EBER EBV-encoded RNA, LDH lactate dehydrogenase, n+ tumour cell-positive, PD-L1 programmed cell death-ligand, R reaction, sIL2R soluble interleukin 2 receptor, TCR T cell receptor, TFH T follicular helper
  2. p-values were analysed using the generalized Wilcoxon method