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Table 2 Histological, immunohistological findings and TCRγ gene in 21 rheumatoid arthritis (RA) patients with other iatrogenic immunodeficiency-associated (OIIA) T- and NK-cell lymphoproliferative disorders (LPDs)

From: Clinicopathological findings, prognosis, and Epstein–Barr virus infection in rheumatoid arthritis patients with other iatrogenic immunodeficiency-associated T- and NK-cell lymphoproliferative disorders

No.

Biopsy site

Atypical lymphoid cell size

Phenotype of atypical lymphocytes

TFH markers (#)

CD30

p53

CMYC

EBV (Latency)

TCR βF1

TCRγ gene clonality

Histological diagnosis

1

LN

Large

CD4+

+ (3)

+

+

+

+

TFH+ PTCL

2

Pharynx

Large

CD4+

+ (4)

+

+

−*

+

TFH+ PTCL

3

LN

Large

CD4+

+ (5)

+

+

−**

+

TFH+ PTCL

4

LN

Small

CD4+

+ (4)

−*

+

TFH+ PTCL

5

LN

Small

CD4+

+ (2)

−*

+

TFH+ T-LPDs

6

LN

Small

CD4+

+ (2)

−**

+

TFH+ T-LPDs

7

LN

Small

CD4+

+ (2)

−*

+

TFH+ T-LPDs

8

LN

Large

CD4+, CD3-

− (0)

+

+

+

+ (II)

+

PTCL-NOS

9

LN

Large

CD4+

− (0)

+

+ (II)

nt

PTCL-NOS

10

LN

Small

CD4+

− (1)

+

T-LPDs

11

LN

Small

CD4+

− (1)

−*

+

T-LPDs

12

LN

Large

CD8+

− (0)

+

+

+

−*

+

nt

systemic ALCL

13

Liver

Large

CD8+

− (1)

+

+

+ (II)

nt

systemic EBV+ TCL of childhood

14

BM

Large

CD8+

− (1)

+

+

+ (I)

+

+

systemic EBV+ TCL of childhood

15

BM, LN

Small

CD8+

− (1)

+

+

T-LGL

16

BM

Small

CD8+

− (0)

+

+

T-LGL

17

LN

Small

CD8+

− (0)

−**

+

+

PTCL-NOS

18

BM

Small

CD8+

− (1)

nt

HLH

19

LN

Small

CD8+

− (1)

−*

+

T-LPDs

20

Subcutis

Small

CD8+

− (1)

+

Panniculitis-like T-LPDs

21

Nose

Large

CD4−, CD8−

− (1)

+

+

+

+ (II)

+

+

Nasal type TCL

Total

na

na

na

7

7

8

5

5

15

9/17

na

  1. ALCL anaplastic large cell lymphoma, BM bone marrow, EBV Epstein–Barr virus, HLH hemophagocytic lymphohistiocytosis, LGL large granular lymphocytosis, LN lymph node, NOS not otherwise specified, PTCL peripheral T-cell lymphoma, TCL T-cell lymphoma, TCR T-cell receptor, TFH T follicular helper
  2. #, positive markers in examined five antibodies; +, tumour cell-positive; *, **, scattered EBER+ small (*) and large (**) lymphocytes in background; na, not available, nt, not test.