Fig. 3

IMPDH1 is upregulated in HCC and promotes tumor growth in HCC patient-derived xenograft models. A, B Overall survival of 381 HCC patients stratified by mRNA abundance of IMPDH1 with or without MYBL2. Data was from TCGA database. C Protein expression of IMPDH1 in 35 HCC tumors and matched adjacent normal tissues determined by immunohistochemical (IHC) analysis using tissue microarray. Representative images of matched tumor and normal tissues were shown. D IHC scores of IMPDH1 in HCC tumors and normal adjacent tissues in C Individual data points are shown with mean and SD. *** P < 0.001. E Growth curve of xenografts (n = 6 in each group) derived from HCC patients with high or low IMPDH1 levels determined by IHC staining. Individual data points are shown with mean and SD. ** P < 0.01