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Fig. 2 | BMC Cancer

Fig. 2

From: MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells

Fig. 2

MYBL2 mRNA and protein expression strongly correlates with IMPDH1 in HCC. A MYBL2 mRNA abundance correlates with molecular subtypes of HCC patients. mRNA abundance of AFP, GMPS, IMPDH1, IMPDH2, MYBL2 and MYC, and patient clinical data were shown, data was from TCGA database. B, C KEGG gene signatures [32,33,34] and purine metabolism gene set correlating with MYBL2 mRNA abundance. Enrichment significance were evaluated with Gene Set Enrichment Analysis (GSEA). D, E Correlation of IMPDH1 and IMPDH2 mRNA abundance with MYBL2 mRNA abundance, data was from TCGA database. F Protein expression of MYBL2 and IMPDH1 in 35 HCC tumors determined by immunohistochemical (IHC) analysis using serial section tissue microarray. Representative images of matched serial tumor sections were shown. G Correlation of IMPDH1 protein abundance with MYBL2 protein abundance determined by mean density of IHC staining in F

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