Table 3 Prognostic variables associated with overall survival and disease free survival

Variable

Level

N

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Age, years

Per unit increase

533

1.06 (1.05, 1.08)

< 0.001

1.07 (1.06, 1.09)

< 0.001

1.04 (1.03, 1.05)

< 0.001

1.05 (1.03, 1.06)

< 0.001

Sex

Female

218

ref

0.019

ref

0.123

ref

0.204

ref

0.598

Male

315

1.33 (1.05, 1.68)

1.27 (0.94, 1.71)

1.15 (0.93, 1.42)

1.07 (0.83, 1.40)

Immunosuppression

No

456

ref

< 0.001

ref

< 0.001

ref

0.041

ref

0.043

Yes

77

1.76 (1.29, 2.41)

2.59 (1.73, 3.89)

1.34 (1.01, 1.79)

1.49 (1.03, 2.16)

Tumour size, cm

Per unit increase

401

1.11 (1.04, 1.18)

0.002

1.16 (1.03, 1.31)

0.019

1.06 (0.99, 1.13)

0.089

1.07 (0.96, 1.19)

0.235

Margins

Negative

288

ref

0.338

ref

0.706

ref

0.801

ref

0.223

Positive

145

1.14 (0.87, 1.49)

0.94 (0.70, 1.28)

0.97 (0.76, 1.24)

0.84 (0.64, 1.11)

Nodal status

Negative

302

ref

< 0.001

ref

< 0.001

ref

< 0.001

ref

< 0.001

Positive

231

1.75 (1.39, 2.21)

2.28 (1.68, 3.09)

1.64 (1.33, 2.02)

2.36 (1.80, 3.10)