Inclusion Criteria | Non-Inclusion criteria |
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- Age ≥ 18 years. - HN cancer in remission: absence of clinical or radiological signs of progression at least 3 months after specific treatments. - Pain of the cervico-facial sphere persisting for more than 3 months after surgical and/or radiotherapy treatment. - Peripheral neuropathic character of pain objectified as a score ≥ 4/10 on the DN4 questionnaire. - Average pain intensity over the past 24 hours assessed on the numerical scale as ≥2/10. - Postmenopausal patient or patient who agrees to use effective contraception for the duration of treatment and for a minimum of 15 days after the end of the treatment period. Non-menopausal patients must have a negative pregnancy test prior to inclusion in the study. - Patient affiliated to a Social Health Insurance in France. - Patient who signed informed consent prior to inclusion in the study and prior to any specific study procedures. | - HN cancer progression. - Other concomitant neoplasia (progressive or not). - Central pain etiology. - Average pain intensity over the past 24 hours is assessed on the numerical scale as < 2/10. - Allergy to any of the components of the capsaicin patch. - Capsaicin patch cannot be applied to the area to be treated despite taking the precautions described in the protocol because of proximity to mucous membranes or eyelids. - Contraindication of amitriptyline treatment. - Patient with an unhealed skin lesion on the area to be treated. - Previous course of capsaicin or amitriptyline treatment. - Topical treatment of the painful area used for more than 21 days before inclusion. - Ongoing opioid treatment > 80 mg/day oral morphine equivalent. - Uncontrolled high blood pressure or cardiovascular history (infarction, stroke, pulmonary embolism) less than 3 months ago. - Patient included in another interventional therapeutic trial. - Pregnant or breastfeeding patient. - Any psychological, family, geographical or sociological condition that prevents compliance with the medical follow-up and/or procedures of the study protocol. - Patient who has forfeited his/her freedom through an administrative or judicial sentence or who is under legal custody (curatorship and guardianship, protection of justice). |