Fig. 2
From: Speckle-type POZ protein could play a potential inhibitory role in human renal cell carcinoma
The effect of SPOP expression on the invasion and migration of RCC cells. (A) Five high-power fields were randomly selected to count the number of invading cells under a microscope after incubation in transwell inserts for 48 h. Cell invasion was significantly decreased in the SPOP high expression group compared with the SPOP low expression group (****, P < 0.0001). (B) Cell migration was determined by the wound-healing assay, and the scratch migration area was calculated using the ImageJ software after 0 h and 24 h. Overexpression of SPOP significantly inhibited the invasion ability of Caki-1 and Caki-2 cells (**, P < 0.01), and a trend towards a statistically significant difference was observed in ACHN cells. (P = 0.0649, ns)