Fig. 5
Eribulin fails to reverse the survival benefit provided by CAF ECMs. A Illustration showing the used experimental conditions whereby eribulin was added to nutrient-deprived cancer cells cultured within intact CAF-generated decellularized CDMs. B The graph shows the survival percentage of RFP-expressing Panc-1 cells treated with DMSO, eribulin, SB431542, or paclitaxel cultured for 24 h in intact CAF-generated CDMs. CDMs obtained from SB431542 treated and β5KO CAFs (as in Fig. 4C) served as “normalized” CDM controls. Data were normalized to DMSO veh., which average was set as 100% survival. For statistical significance, a one-way ANOVA (Turkey’s multiple comparisons) test was used to compare all conditions. Black asterisks denote comparisons to DMSO, while the eribulin vs. paclitaxel comparison is noted in orange. * P < 0.05; ** p < 0.01; *** P < 0.001; **** p < 0.0001