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Fig. 3 | BMC Cancer

Fig. 3

From: Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating selected features of TGFβ inhibition

Fig. 3

CAFs treated with eribulin generate ECMs that fail to induce a normal-to-CAF transition. A Illustration showing naïve fibroblasts re-plated into decellularized CDMs obtained from eribulin-treated CAFs. B Representative confocal immunofluorescent images showing monochromatic reconstitutions of αSMA and stress fibers (F-actin). Accompanying box and whiskers graph representing ratios of αSMA localization at F-actin positive pixels (error bars = maximum and minimum values while all median measured values are shown as individual squares). For statistical significance, ordinary one-way ANOVA was used comparing all data to the DMSO veh. control. * P < 0.05; ** p < 0.01; *** P < 0.001; **** p < 0.0001

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