Variables | Time to treatment failure | Progression-free-survival | Overall survival | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate | Multivariableb | Univariate | Multivariablec | Univariate | Multivariabled | |||||||
HR | P | HR | P | HR | P | HR | P | HR | P | HR | P | |
(β) | (β) | (β) | ||||||||||
Characteristics | ||||||||||||
Sex (female vs. male) | 0.987 | 0.960 | 1.115 | 0.682 | 0.890 | 0.734 | ||||||
Age (≥ 65 vs. < 65 years) | 1.624 | 0.024 | 1.256 | 0.290 | 0.822 | 0.474 | ||||||
ECOG PS (≥ 2 vs. 0, 1) | 1.520 | 0.165 | 1.452 | 0.216 | 2.599 | 0.012 | ||||||
MSKCC risk group (poor vs. others) | 2.934 | < 0.001 | 3.340 | < 0.001 | 3.234 | < 0.001 | 9.115 | < 0.001 | 7.239 | < 0.001 | ||
(1.174) | (1.979) | |||||||||||
Prior nephrectomy (yes vs. no) | 0.651 | 0.071 | 0.650 | 0.068 | 0.308 | < 0.001 | ||||||
Number of metastatic sites (≥ 2 vs. 0, 1) | 1.960 | 0.002 | 2.322 | < 0.001 | 2.369 | < 0.001 | 2.273 | < 0.001 | 2.756 | 0.001 | 3.260 | < 0.001 |
(0.842) | (0.821) | (1.182) | ||||||||||
Treatment (2, 3 vs. 1st line) | 1.023 | 0.921 | 1.188 | 0.455 | 1.131 | 0.687 | ||||||
6-week RDI (< 60 vs. ≥ 60%) | 2.671 | < 0.001 | 3.160 | < 0.001 | 1.321 | 0.190 | 1.581 | 0.095 | ||||
(1.151) | ||||||||||||
Duration of therapy (< 6 vs. ≥ 6 weeks) | ― | ― | 2.375 | < 0.001 | 2.088 | 0.014 | ||||||
Adverse eventsa | ||||||||||||
Hypertension (no vs. yes) | 1.371 | 0.136 | 1.194 | 0.412 | 2.169 | 0.005 | 2.073 | 0.024 | ||||
(0.729) | ||||||||||||
Hand-foot syndrome (no vs. yes) | 1.537 | 0.046 | 1.529 | 0.049 | 1.664 | 0.043 | 1.203 | 0.499 | ||||
(0.509) | ||||||||||||
Diarrhea (no vs. yes) | 0.668 | 0.080 | 0.673 | 0.087 | 0.563 | 0.047 | 1.903 | 0.066 | ||||
(0.643) | ||||||||||||
Hypothyroidism (no vs. yes) | 1.495 | 0.099 | 1.414 | 0.154 | 1.085 | 0.790 | ||||||
Leukopenia (no vs. yes) | 0.832 | 0.389 | 0.650 | 0.047 | 0.704 | 0.206 | ||||||
Thrombocytopenia (no vs. yes) | 1.263 | 0.350 | 0.942 | 0.814 | 1.649 | 0.112 | ||||||
Elevation of ALP (no vs. yes) | 0.740 | 0.159 | 0.695 | 0.093 | 0.457 | 0.007 | ||||||
Laboratory data at start of sunitinib | ||||||||||||
Hb (≥ 12 vs. < 12 g/dL) | 0.504 | 0.001 | 0.514 | 0.002 | 0.280 | < 0.001 | ||||||
Ca (≥ 10 vs. < 10 g/dL) | 1.841 | 0.029 | 1.987 | 0.017 | 4.009 | < 0.001 | ||||||
LDH (> 333 vs. ≤ 333 U/L) | 5.395 | < 0.001 | 7.278 | < 0.001 | 14.550 | < 0.001 | ||||||
AST (> 30 vs. ≤ 30 U/L) | 2.160 | 0.003 | 2.303 | 0.009 | 2.060 | 0.006 | 2.689 | 0.002 | ||||
(0.834) | ||||||||||||
Alb (≥ 3.5 vs. < 3.5 g/dL) | 0.550 | 0.008 | 0.469 | 0.001 | 0.225 | < 0.001 | ||||||
CRP (> 0.5 vs. ≤ 0.5 g/dL) | 2.239 | < 0.001 | 2.055 | 0.001 | 4.465 | < 0.001 | ||||||
ALP (> 322 vs. ≤ 322 U/L) | 2.102 | < 0.001 | 1.811 | 0.013 | 2.253 | < 0.001 | 3.134 | < 0.001 | ||||
(0.594) | ||||||||||||
mGPS (1, 2 vs. 0) | 2.037 | 0.001 | 2.134 | < 0.001 | 5.119 | < 0.001 | 2.946 | 0.005 | ||||
(1.080) | ||||||||||||
NLR (> 3.5 vs. ≤ 3.5) | 1.319 | 0.207 | 1.519 | 0.059 | 3.080 | < 0.001 | ||||||
PLT (> 310 vs. ≤ 310 × 109 /L) | 1.318 | 0.223 | 1.457 | 0.098 | 2.290 | 0.005 | ||||||
COP-NLR (1, 2 vs. 0) | 1.271 | 0.256 | 1.327 | 0.184 | 2.823 | < 0.001 | ||||||
Laboratory data within the first 6 weeks of sunitinib | ||||||||||||
Hb (≥ 12 vs. < 12 g/dL) | 0.611 | 0.020 | 0.507 | 0.002 | 0.270 | < 0.001 | ||||||
Ca (≥ 10 vs. < 10 g/dL) | 3.798 | < 0.001 | 3.639 | < 0.001 | 5.053 | < 0.001 | ||||||
LDH (> 333 vs. ≤ 333 U/L) | 2.218 | 0.001 | 2.397 | < 0.001 | 3.531 | < 0.001 | ||||||
AST (> 30 vs. ≤ 30 U/L) | 1.311 | 0.202 | 1.414 | 0.107 | 1.185 | 0.536 | ||||||
Alb (≥ 3.5 vs. < 3.5 g/dL) | 0.527 | 0.003 | 0.510 | 0.002 | 0.396 | 0.001 | ||||||
CRP (> 0.5 vs. ≤ 0.5 g/dL) | 1.732 | 0.026 | 1.718 | 0.034 | 1.421 | 0.286 | ||||||
mGPS (1, 2 vs. 0) | 1.749 | 0.026 | 1.765 | 0.030 | 1.348 | 0.366 | ||||||
NLR (> 3.5 vs. ≤ 3.5) | 2.898 | < 0.001 | 2.799 | < 0.001 | 4.357 | < 0.001 | ||||||
PLT (> 310 vs. ≤ 310 × 109 /L) | 5.578 | < 0.001 | 5.142 | < 0.001 | 7.758 | < 0.001 | ||||||
COP-NLR (1, 2 vs. 0) | 2.898 | < 0.001 | 2.255 | 0.003 | 2.799 | < 0.001 | 2.270 | 0.004 | 4.357 | < 0.001 | 2.860 | 0.002 |
(0.813) | (0.820) | (1.051) |