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Table 5 Diagnostic performance of all parameters in predicting pCR after NAC

From: Early prediction of pathological complete response to neoadjuvant chemotherapy combining DCE-MRI and apparent diffusion coefficient values in breast Cancer

Parameters

AUC

Cutoff

Sensitivity

Specificity

PPV

NPV

P value

Ktrans (min-1)

0.825

≤0.073

83.33

75.79

0.433

0.998

<0.001*

Kep (min-1)

0.805

≤0.169

62.50

92.63

0.257

0.965

<0.001*

Ve(%)

0.542

≤0.204

45.83

71.58

1.064

0.919

0.572

IAUC

0.824

≤0.083

83.33

78.95

0.388

0.998

<0.001*

ADC

0.721

>0.981

87.50

56.84

0.312

0.998

<0.001*

W-in

0.866

≤0.092

83.33

84.21

1.095

0.397

<0.001*

W-out

0.572

>0.009

62.50

58.95

0.623

0.405

0.238

TTP

0.725

>0.582

100.00

42.11

0.304

0.457

<0.001*

Ktrans + Kep +IAUC

0.836

>-0.721

70.83

85.26

0.642

0.724

<0.001*

Ktrans+Kep+IAUC+ADC

0.845

>-0.223

62.50

95.79

0.657

0.973

<0.001*

W-in+TTP

0.865

>-0.684

83.33

84.21

0.486

0.735

<0.001*

W-in+TTP+ADC

0.886

>-0.811

87.50

82.11

0.441

0.711

<0.001*

  1. *P value <0.05, indicating that the differences were considered statistically significant. Abbreviations: PPV Positive predictive value, NPV Negative predictive value