Multiplexed immunofluorescence analysis of CAF-markers, EZH2 and FOXM1 in gastric tissue: associations with clinicopathological parameters and clinical outcomes

Table 2 Univariate and multivariate analyses of clinicopathological factors for overall survival in gastric cancer patients

Variable	Univariate analysis		Multivariate analysis
Variable	HR (95% CI)	p^a	HR (95% CI)	p^a
Age (≥ 60/< 60)	0.896 (0.519-1.548)	0.695
Gender (Male/Female)	0.984 (0.493-1.963)	0.963
Location (Cardia/ Fundus/ Antrum/Other)	1.047 (0.773-1.418)	0.767
Tumor mass size (≥ 5/< 5)	1.739 (0.997-3.031)	0.051
Histologic grade (Poor, Undifferented /Good, mod)	1.007 (0.512-1.981)	0.984
Tumor depth (T3, T4/T1, T2)	1.509 (0.733-3.108)	0.264
Vascular invasion (Present/Absent)	2.268 (1.239-4.152)	0.008
Nervous invasion (Present/Absent)	1.442 (0.825-2.521)	0.198
Lymphatic metastasis (Present/Absent)	3.867 (1.534-9.748)	0.004	3.300 (1.276-8.533)	0.014
Peritoneal metastasis (Present/Absent)	2.137 (1.164-3.922)	0.014
pTNM stage (III + IV/I + II)	2.104 (1.137-3.891)	0.018
FOXM1 protein (High/Low)	1.007 (0.581-1.747)	0.980
FAP protein (High/Low)	1.939 (1.120-3.357)	0.018
EZH2 protein (High/Low)	3.544 (1.102-11.395)	0.034	3.584 (1.110-11.570)	0.033

HR Hazard ratio, CI confidence interval; ^a All statistical tests were 2-sided. Significance level: p < 0.05

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