Multiplexed immunofluorescence analysis of CAF-markers, EZH2 and FOXM1 in gastric tissue: associations with clinicopathological parameters and clinical outcomes

Table 1 Clinical characteristics of gastric cancer patients

Variables		EZH2 expression		P value	FAP expression		P value	FOXM1 expression		P value
Variables		Low (n = 14)	High (n = 79)	P value	Low (n = 51)	High (n = 42)	P value	Low (n = 59)	High (n = 34)	P value
Age	< 60	8	38	0.533	23	23	0.354	32	14	0.225
Age	≥60	6	41		28	19		27	20
Sex	Male	10	65	0.344	41	34	0.946	48	27	0.819
Sex	Female	4	14		10	8		11	7
Tumor location	Cardia/Proximal	1	16	0.005*	8	9	0.527	13	4	0.547
	Fundus/Body	2	27		14	15		19	10
	Antrum/Distal	11	23		20	14		20	14
	Other	0	13		9	4		7	6
Tumor size	< 5 cm	11	51	0.305	35	27	0.658	40	22	0.761
Tumor size	≥ 5 cm	3	28		16	15		19	12
Histologic grade	Poor or undifferentiated	11	58	0.919	40	29	0.527	44	25	0.919
Histologic grade	Good or moderate	3	17		10	10		13	7
Vascular invasion	Absent	6	33	0.940	20	19	0.558	21	18	0.103
Vascular invasion	Present	8	46		31	23		38	16
Nervous invasion	Absent	8	35	0.375	23	20	0.808	28	15	0.756
Nervous invasion	Present	6	44		28	22		31	19
Tumor invasion depth	T1 + 2	4	15	0.412	11	8	0.764	8	11	0.030^*
Tumor invasion depth	T3 + 4	10	64		40	34		51	23
lymphatic metastasis	Absent	3	18	0.911	14	7	0.216	13	8	0.868
lymphatic metastasis	Present	11	61		37	35		46	26
M stage	M0	10	60	0.718	39	31	0.767	42	28	0.229
M stage	M1	4	19		12	11		17	6
TNM stage	I + II	4	29	0.558	19	14	0.694	18	15	0.186
TNM stage	III + IV	10	50		32	28		41	19

ISSN: 1471-2407