Fig. 1
From: Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer
Mutant KRAS suppresses splicing factor phosphorylation in lung epithelial cells. A Phosphorylation changes in SR proteins (blue) or other proteins (gray) in KRASG12V or KRASQ61H vs KRASWT cells, and RIT1M90I vs RIT1WT cells; * p < 0.05, **** p < 0.0001 by one-sided Wilcoxon rank-sum test. B Volcano plots of the phosphorylation changes in mRNA splicing proteins. Sites with less phosphorylation in KRASG12V or KRASQ61H compared to KRASWT are shown in blue, sites with more phosphorylation are shown in red. The most significantly altered SR protein phosphosites are labeled. C Heatmap of phosphorylation changes in phosphosites of RNA splicing proteins of interest SF3B2, SRSF1, SRSF2, SRSF4, and SRSF7