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Table 3 Analysis of immune function and laboratory indexes in 303 patients with lung cancer

From: Broad-spectrum antibiotics associated gut microbiome disturbance impairs T cell immunity and promotes lung cancer metastasis: a retrospective study

Characteristic

Non-ATB (n = 158)

ATB (n = 145)

P value

CD3+ (%)

69.60 (63.96,75.70)

65.50 (55.25,71.00)

< 0.001

CD4+ (%)

43.20 ± 10.49

34.81 ± 10.98

< 0.001

CD8+ (%)

23.30 (17.02,28.30)

20.30 (15.34,24.25)

< 0.001

CD4/CD8

1.90 (1.37,2.57)

1.70 (1.20,2.25)

0.146

CD16 + 56+ (%)

14.80 (10.10,21.75)

18.00 (12.60,25.05)

0.002

CD19+ (%)

9.36 (6.50,13.38)

9.50 (6.00,15.05)

0.709

C3 (g/L)

1.06 (0.87,1.21)

1.07 (0.90,1.22)

0.523

IgG (g/L)

12.25 (10.22,14.58)

11.95 (9.73,15.08)

0.837

IgA (g/L)

2.54 (1.84,3.17)

2.67 (1.77,3.71)

0.349

IgM (g/L)

0.86 (0.63,1.27)

0.84 (0.55,1.09)

0.110

C4 (g/L)

0.26 (0.21,0.33)

0.26 (0.19,0.31)

0.376

WBC(*10^9/L)

8.64 (6.11,11.37)

9.27 (6.78,13.51)

0.071

L%

16.70 (11.00,23.40)

12.90 (8.20,20.20)

0.003

NLR

4.42 (2.77,6.95)

5.68 (3.53,10.40)

0.003

PLT(*10^9/L)

239.00 (183.50,291.50)

221.00 (178.00,311.00)

0.853

CRP (mg/L)

20.16 (4.05,68.36)

27.73 (7.28,94.99)

0.045

PCT (ng/L)

1.64 (0.11,4.37)

2.13 (0.82,4.85)

0.076

D-Dimer (mg/L)

1.03 (0.49,2.67)

2.46 (0.93,5.21)

< 0.001

  1. WBC white blood cell, L% Percentage of lymphocytes, NLR Neutrophil-lymphocyte ratio, PLT platelet, CRP C-reactive protein, PCT Procalcitonin, C3 Complement C3, IgG Immunoglobulin G, IgA Immunoglobulin A, IgM Immunoglobulin M, C4 Complement C4