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Table 6 SNP–SNP interaction models of candidate SNPs analyzed by the MDR method

From: Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population

Model

Training Bal. Acc.

Testing Bal. Acc.

CVC

OR (95% CI)

p

rs9864693

0.5315

0.499

8/10

1.28 (1.00-1.63)

0.0517

rs3802967,rs9864693

0.5428

0.4824

4/10

1.42 (1.10–1.85)

0.0078*

rs3802967,rs9864693,rs4150658

0.5628

0.5207

8/10

1.67 (1.29–2.14)

< 0.0001*

rs3802967,rs4687721,rs9864693,rs4150658

0.5815

0.4855

3/10

1.99 (1.53–2.58)

< 0.0001*

rs3802967,rs9864693,rs11720298,rs4150658,rs4687592

0.6098

0.5158

5/10

2.47 (1.89–3.23)

< 0.0001*

rs3802967,rs9864693,rs11720298,rs4150658,rs4150667,rs4687592

0.6344

0.5276

8/10

2.92 (2.62–3.76)

< 0.0001*

rs3802967,rs9864693,rs11720298,rs4150606,rs4150658,rs4150667,rs4687592

0.644

0.5217

9/10

3.13 (2.42–4.04)

< 0.0001*

rs3802967,rs4687721,rs9864693,rs11720298,rs4150606,rs4150658,rs4150667,rs4687592

0.6507

0.5286

10/10

3.34 (2.58–4.32)

< 0.0001*

rs3802967,rs4687721,rs9864693,rs11720298,rs4150530,rs4150606,rs4150658,rs4150667,rs4687592

0.6523

0.5306

10/10

3.40 (2.62–4.40)

< 0.0001*

  1. MDR multifactor dimensionality reduction, Bal. Acc. balanced accuracy, CVC cross–validation consistency, OR odds ratio, CI confidence interval
  2. p values were calculated using χ2 tests
  3. Bold indicate that p < 0.05 indicates statistical significance