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Table 5 False-positive report probability values for the associations between RAD54L2 and GTF2H1 polymorphisms and the risk of lung cancer

From: Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population

SNP

Model

adjusted by age and sex

Statistical power

Prior probability

OR (95%CI)

p

0.25

0.1

0.01

0.001

0.0001

Overall

RAD54L2 rs9864693

Genotype

1.33 (1.01–1.77)

0.045

0.795

0.160a

0.364

0.863

0.984

0.998

Age ≤ 59 years

RAD54L2 rs11720298

Genotype

0.61 (0.41–0.90)

0.013

0.842

0.043a

0.120a

0.600

0.938

0.993

dominant

0.60 (0.42–0.87)

0.007

0.832

0.025a

0.071a

0.456

0.894

0.988

log-additive

0.69 (0.51–0.92)

0.012

0.986

0.034a

0.095a

0.535

0.921

0.991

RAD54L2 rs4687592

dominant

1.49 (1.03–2.14)

0.034

0.944

0.089a

0.227

0.764

0.970

0.997

log-additive

1.35 (1.03–1.76)

0.028

0.998

0.074a

0.193a

0.725

0.964

0.996

RAD54L2 rs9864693

Genotype

1.60 (1.06–2.40)

0.025

0.860

0.075a

0.195a

0.727

0.964

0.996

 

1.75 (1.03–2.99)

0.039

0.687

0.150a

0.347

0.854

0.983

0.998

dominant

1.64 (1.12–2.40)

0.012

0.846

0.037a

0.104a

0.560

0.928

0.992

log-additive

1.37 (1.05–1.77)

0.019

0.756

0.060a

0.160a

0.677

0.955

0.995

GTF2H1 rs4150667

log-additive

1.32 (1.00–1.75)

0.048

0.813

0.165a

0.373

0.867

0.985

0.998

BMI ≤ 24 kg/m 2

GTF2H1 rs4150667

Genotype

0.18 (0.05–0.65)

0.009

0.059

0.309

0.573

0.937

0.993

0.999

recessive

0.18 (0.05–0.63)

0.008

0.055

0.285

0.544

0.929

0.993

0.999

Non-smokers

RAD54L2 rs11720298

Genotype

0.28 (0.11–0.75)

0.011

0.124

0.215

0.451

0.900

0.989

0.999

dominant

0.63 (0.40–0.99)

0.047

0.842

0.138a

0.325

0.841

0.982

0.998

recessive

0.33 (0.13–0.85)

0.021

0.195

0.250

0.500

0.917

0.991

0.999

log-additive

0.62 (0.43–0.89)

0.011

0.878

0.032a

0.089a

0.518

0.916

0.991

Drinkers

RAD54L2 rs11720298

Genotype

0.17 (0.05–0.63)

0.008

0.053

0.311

0.575

0.937

0.993

0.999

log-additive

0.54 (0.35–0.85)

0.008

0.630

0.036a

0.100a

0.549

0.925

0.992

RAD54L2 rs4687592

Genotype

2.54 (1.07–6.00)

0.034

0.293

0.256

0.508

0.919

0.991

0.999

log-additive

1.53 (1.03–2.28)

0.035

0.906

0.108a

0.267

0.800

0.976

0.998

Lung squamous cell carcinoma

GTF2H1 rs3802967

dominant

0.68 (0.46–0.99)

0.045

0.946

0.123a

0.296

0.822

0.979

0.998

  1. SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
  2. p values were calculated by logistic regression analysis with adjustments for age
  3. Statistical power was calculated using the number of observations in the subgroup and the OR and p values in this table
  4. aThe level of false-positive report probability threshold was set at 0.2, and noteworthy findings are presented