Table 2 Univariate and multivariate Cox regression analyses

T stage

539

 T1&T2

349

Reference

 T3&T4

190

3.228 (2.382–4.374)

< 0.001

2.055 (1.300-3.250)

0.002

N stage

257

 N0

241

Reference

 N1

16

3.453 (1.832–6.508)

< 0.001

1.602 (0.815–3.148)

0.171

M stage

506

 M0

428

Reference

 M1

78

4.389 (3.212–5.999)

< 0.001

3.089 (1.922–4.963)

< 0.001

Gender

539

 Female

186

Reference

 Male

353

0.930 (0.682–1.268)

0.648

Age

539

  ≤ 60

269

Reference

  > 60

270

1.765 (1.298–2.398)

< 0.001

1.858 (1.216–2.840)

0.004

CX3CL1

539

0.688 (0.609–0.776)

< 0.001

0.682 (0.562–0.826)

< 0.001