Variable | OSa | PFSb | LRFSc | DMFSd | ||||
---|---|---|---|---|---|---|---|---|
HRe (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
T stage (T4 vs. T1–3) | 1.365 (1.012–1.840) | 0.041 | 1.309 (1.027–1.668) | 0.030 | 1.883 (1.219–2.907) | 0.004 | 1.218 (0.874–1.696) | 0.245 |
N stage (N2–3 vs. N0–1) | 1.230 (0.906–1.670) | 0.184 | 1.217 (0.950–1.559) | 0.121 | 0.765 (0.497–1.175) | 0.221 | 1.890 (1.310–2.726) | 0.001 |
Combination of cumulative smoking consumption and pre-treatment EBVf |  | < 0.001 |  | < 0.001 |  | 0.085 |  | < 0.001 |
Group 1: < 30 pack-years and pre-treatment EBV < 1500 | Reference | Reference | Reference | Reference | ||||
Group 2: ≥30 pack-years and pre-treatment EBV < 1500 | 1.836 (1.127–2.991) | 0.015 | 1.394 (0.933–2.083) | 0.105 | 0.806 (0.384–1.692) | 0.568 | 1.090 (0.574–2.069) | 0.792 |
Group 3: < 30 pack-years and pre-treatment EBV ≥ 1500 | 2.519 (1.703–3.728) | < 0.001 | 2.669 (1.974–3.608) | < 0.001 | 1.700 (1.035–2.793) | 0.036 | 3.055 (2.012–4.639) | < 0.001 |
Group 4: ≥30 pack-years and pre-treatment EBV ≥ 1500 | 3.614 (2.308–5.658) | < 0.001 | 2.912 (2.010–4.219) | < 0.001 | 1.515 (0.770–2.981) | 0.229 | 3.422 (2.058–5.691) | < 0.001 |