Characteristic | Total patients (N = 1080) | Male patients (N = 793) | PSM matched male patients (N = 566) | ||||||
---|---|---|---|---|---|---|---|---|---|
Never smokers (N = 621) n (%) | Ever smokers (N = 459) n (%) | P value* | Never smokers (N = 338) n (%) | Ever smokers (N = 455) n (%) | P value* | Never smokers (N = 283) n (%) | Ever smokers (N = 283) n (%) | P value# | |
Sex |  |  | < 0.001 |  |  | – |  |  | – |
 Female | 283 (45.6%) | 4 (0.9%) |  | 0 (0) | 0 (0) |  | 0 (0) | 0 (0) |  |
 Male | 338 (54.4%) | 455 (99.1%) |  | 338 (100%) | 455 (100%) |  | 283 (100%) | 283 (100%) |  |
Age (years) |  |  | < 0.001 |  |  | < 0.001 |  |  | 1.000 |
  < 45 | 321 (50.2%) | 161 (35.1%) |  | 177 (52.4%) | 160 (35.2%) |  | 133 (47.0%) | 132 (46.6%) |  |
  ≥ 45 | 309 (49.8%) | 298 (64.9%) |  | 161 (47.6%) | 295 (64.8%) |  | 150 (53.0%) | 151 (53.4%) |  |
Overall stageb | Â | Â | 0.050 | Â | Â | 0.051 | Â | Â | 0.706 |
 I | 48 (7.7%) | 28 (6.1%) |  | 26 (7.7%) | 28 (6.2%) |  | 25 (8.8%) | 22 (7.8%) |  |
 II | 90 (14.5%) | 55 (12.0%) |  | 55 (16.3%) | 55 (12.1%) |  | 40 (14.1%) | 39 (13.8%) |  |
 III | 211 (34.0%) | 133 (29.6%) |  | 112 (33.1%) | 133 (29.2%) |  | 86 (30.4%) | 86 (30.4%) |  |
 IV | 272 (43.8%) | 239 (52.3%) |  | 145 (42.9%) | 239 (52.5%) |  | 132 (46.6%) | 136 (48.1%) |  |
Tumor stageb | Â | Â | 0.059 | Â | Â | 0.044 | Â | Â | 0.085 |
 T1 | 129 (20.8%) | 93 (20.3%) |  | 70 (20.7%) | 93 (20.4%) |  | 62 (21.9%) | 66 (23.3%) |  |
 T2 | 127 (20.5%) | 86 (18.7%) |  | 70 (20.7%) | 84 (18.5%) |  | 57 (20.1%) | 57 (20.1%) |  |
 T3 | 133 (21.4%) | 75 (16.3%) |  | 76 (22.5%) | 74 (16.3%) |  | 52 (18.4%) | 41 (14.5%) |  |
 T4 | 232 (37.4%) | 205 (44.7%) |  | 122 (36.1%) | 204 (44.8%) |  | 112 (39.6%) | 119 (42.0%) |  |
Node stageb | Â | Â | 0.295 | Â | Â | 0.052 | Â | Â | 0.192 |
 N0 | 97 (17.8%) | 64 (13.9%) |  | 60 (17.8%) | 64 (14.1%) |  | 50 (17.7%) | 50 (17.7%) |  |
 N1 | 188 (32.8%) | 125 (27.2%) |  | 111 (32.8%) | 125 (27.5%) |  | 84 (29.7%) | 93 (32.9%) |  |
 N2 | 290 (42.9%) | 224 (48.8%) |  | 145 (42.9%) | 220 (44.8%) |  | 130 (45.9%) | 120 (42.4%) |  |
 N3 | 46 (6.5%) | 46 (10.1%) |  | 22 (6.5%) | 46 (10.1%) |  | 19 (6.7%) | 20 (7.1%) |  |
Alcohol drinking |  |  | < 0.001 |  |  | < 0.001 |  |  | 1.000 |
 No | 605 (97.4%) | 328 (71.5%) |  | 322 (95.3%) | 324 (71.2%) |  | 267 (94.3%) | 267 (94.3%) |  |
 Yes | 16 (2.6%) | 131 (28.5%) |  | 16 (4.7%) | 131 (28.8%) |  | 16 (5.7%) | 16 (5.7%) |  |
Family history of NPC | Â | Â | 0.135 | Â | Â | 0.047 | Â | Â | 1.000 |
 No | 576 (92.8%) | 436 (95.0%) |  | 309 (91.4%) | 432 (94.9%) |  | 265 (93.6) | 264 (93.3%) |  |
 Yes | 45 (7.2%) | 23 (5.0%) |  | 29 (8.6%) | 23 (5.1%) |  | 18 (6.4%) | 19 (6.7%) |  |