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Table 1 Clinical characteristics of patients with NPC

From: Combination of smoking and Epstein-Barr virus DNA is a predictor of poor prognosis for nasopharyngeal carcinoma: a long-term follow-up retrospective study

Characteristic

Total patients (N = 1080)

Male patients (N = 793)

PSM matched male patients (N = 566)

Never smokers

(N = 621)

n (%)

Ever smokers

(N = 459)

n (%)

P value*

Never smokers

(N = 338)

n (%)

Ever smokers

(N = 455)

n (%)

P value*

Never smokers

(N = 283)

n (%)

Ever smokers

(N = 283)

n (%)

P value#

Sex

  

< 0.001

  

–

  

–

 Female

283 (45.6%)

4 (0.9%)

 

0 (0)

0 (0)

 

0 (0)

0 (0)

 

 Male

338 (54.4%)

455 (99.1%)

 

338 (100%)

455 (100%)

 

283 (100%)

283 (100%)

 

Age (years)

  

< 0.001

  

< 0.001

  

1.000

  < 45

321 (50.2%)

161 (35.1%)

 

177 (52.4%)

160 (35.2%)

 

133 (47.0%)

132 (46.6%)

 

  ≥ 45

309 (49.8%)

298 (64.9%)

 

161 (47.6%)

295 (64.8%)

 

150 (53.0%)

151 (53.4%)

 

Overall stageb

  

0.050

  

0.051

  

0.706

 I

48 (7.7%)

28 (6.1%)

 

26 (7.7%)

28 (6.2%)

 

25 (8.8%)

22 (7.8%)

 

 II

90 (14.5%)

55 (12.0%)

 

55 (16.3%)

55 (12.1%)

 

40 (14.1%)

39 (13.8%)

 

 III

211 (34.0%)

133 (29.6%)

 

112 (33.1%)

133 (29.2%)

 

86 (30.4%)

86 (30.4%)

 

 IV

272 (43.8%)

239 (52.3%)

 

145 (42.9%)

239 (52.5%)

 

132 (46.6%)

136 (48.1%)

 

Tumor stageb

  

0.059

  

0.044

  

0.085

 T1

129 (20.8%)

93 (20.3%)

 

70 (20.7%)

93 (20.4%)

 

62 (21.9%)

66 (23.3%)

 

 T2

127 (20.5%)

86 (18.7%)

 

70 (20.7%)

84 (18.5%)

 

57 (20.1%)

57 (20.1%)

 

 T3

133 (21.4%)

75 (16.3%)

 

76 (22.5%)

74 (16.3%)

 

52 (18.4%)

41 (14.5%)

 

 T4

232 (37.4%)

205 (44.7%)

 

122 (36.1%)

204 (44.8%)

 

112 (39.6%)

119 (42.0%)

 

Node stageb

  

0.295

  

0.052

  

0.192

 N0

97 (17.8%)

64 (13.9%)

 

60 (17.8%)

64 (14.1%)

 

50 (17.7%)

50 (17.7%)

 

 N1

188 (32.8%)

125 (27.2%)

 

111 (32.8%)

125 (27.5%)

 

84 (29.7%)

93 (32.9%)

 

 N2

290 (42.9%)

224 (48.8%)

 

145 (42.9%)

220 (44.8%)

 

130 (45.9%)

120 (42.4%)

 

 N3

46 (6.5%)

46 (10.1%)

 

22 (6.5%)

46 (10.1%)

 

19 (6.7%)

20 (7.1%)

 

Alcohol drinking

  

< 0.001

  

< 0.001

  

1.000

 No

605 (97.4%)

328 (71.5%)

 

322 (95.3%)

324 (71.2%)

 

267 (94.3%)

267 (94.3%)

 

 Yes

16 (2.6%)

131 (28.5%)

 

16 (4.7%)

131 (28.8%)

 

16 (5.7%)

16 (5.7%)

 

Family history of NPC

  

0.135

  

0.047

  

1.000

 No

576 (92.8%)

436 (95.0%)

 

309 (91.4%)

432 (94.9%)

 

265 (93.6)

264 (93.3%)

 

 Yes

45 (7.2%)

23 (5.0%)

 

29 (8.6%)

23 (5.1%)

 

18 (6.4%)

19 (6.7%)

 
  1. a Pathologic type according to the 2005 World Health Organization (WHO) classification of tumors
  2. b According to the 7th edition of the AJCC staging system
  3. *Chi-square test or Fisher’s exact test
  4. #Cochran-Mantel-Haenszel chi-squared test