Skip to main content

Table 3 Univariate and multivariate analyses of possible indicators related to overall survival

From: Nomogram-based development and evaluation for predictions of 30-day and 1-year survival in patients with spontaneously ruptured hepatocellular carcinoma

Variables

Median survival time (days)

Univariate analysis

Multivariate analysis

HR

95% CI

P

HR

95% CI

P

Gender (male/female)

170/255

0.668

0.362–1.234

0.198

1.289

0.628–2.644

0.489

Age (years)

 

1.005

0.985–1.026

0.603

0.992

0.970–1.016

0.517

LTS (cm)

 

1.074

1.025–1.126

0.003

1.086

1.021–1.154

0.008

BCLC (A + B/C)

239/59

2.798

1.748–4.481

< 0.001

1.095

1.076–3.372

0.027

Treatment at rupture

 Conservative (control)

48

 TAE/TACE

159

0.565

0.334–0.956

0.033

0.660

0.354–1.231

0.192

 Hepatectomy

466

0.202

0.105–0.388

< 0.001

0.180

0.076–0.427

< 0.001

Blood transfusion (no/yes)

160/381

0.495

0.287–0.854

0.012

1.053

0.540–2.052

0.880

Viral hepatitis (none/HBV + HCV)

184/172

0.977

0.530–1.803

0.941

   

Cirrhosis (no/yes)

207/168

1.394

0.783–2.482

0.259

   

AFP (≤400/> 400)

 

1.549

0.994–2.412

0.053

   

WBC (×109/L)

 

0.992

0.953–1.032

0.686

   

HB (g/L)

 

0.998

0.989–1.007

0.642

   

PT (s)

 

1.137

1.056–1.224

0.001

0.994

0.845–1.055

0.312

ALB (g/L)

 

0.959

0.932–0.988

0.005

0.944

0.905–0.984

0.007

TBil (umol/L)

 

1.015

1.008–1.021

< 0.001

1.021

1.010–1.032

< 0.001

Na+ (mmol/L)

 

0.945

0.892–1.000

0.049

1.040

0.971–1.113

0.266

SCr (umol/L)

 

1.003

0.998–1.009

0.213

   

TACE during follow-up (no/yes)

92/347

0.420

0.255–0.692

0.001

0.414

0.233–0.737

0.003

  1. OR Odds ratio, CI Confidence interval, LTS Largest tumor size, BCLC Barcelona Clinic Liver Cancer score, TAE Transcatheter arterial embolization, TACE Transarterial chemoembolization, HBV Hepatitis B virus, HCV Hepatitis C virus, AFP Alpha-fetoprotein, WBC White blood cell count, HB Hemoglobin, PT Prothrombin time, ALB Albumin, TBil total bilirubin, SCr Serum creatinine