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Table 3 The subgroup analysis in PFS of patients with high TMB compared to low TMB

From: The prognostic role of tumor mutation burden on survival of breast cancer: a systematic review and meta-analysis

Subgroup

Number of study

Effects model

Pooled ES

Heterogeneity

HR [95% CI]

P

I2

P-Value

Type of therapy

 ICIs

4

Fixed

0.52[0.35,0.77]

 < 0.001

50.3%

0.110

 Non-ICIs

5

Random

2.31[0.89,5.97]

0.086

68.5%

0.013

Breast cancer subtype

 HER2 + 

4

Random

3.26[0.64,16.71]

0.156

74.2%

0.009

 TNBC

4

Fixed

0.52[0.35,0.77]

0.001

50.3%

0.110

Sample source

 tumor

5

Fixed

0.53[0.38,0.74]

 < 0.001

35.4%

0.185

 blood

4

Fixed

3.37[1.34,8.44]

0.01

38.1%

0.183

TMB detection method

 NGS

8

Random

1.04[0.54,2.01]

0.909

83.4%

 < 0.001

 WES

1

-

0.63[0.28,1.14]

-

-

-

TMB cutoff value

  ≤ 5 Mut/Mb

4

Fixed

3.37[1.34,8.44]

0.01

38.1%

0.183

  > 5 Mut/Mb

4

Fixed

0.52[0.35,0.77]

0.001

50.3%

0.110