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Fig. 6 | BMC Cancer

Fig. 6

From: The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells

Fig. 6

Schematic illustration of the role of H2A.Z in regulating SFRP1 promoter activity in ICC. In the nucleus, H2A.Z recruits KDM1A, H3K4me1 and H3K4me2 to form a complex to promote demethylation upstream of the SFRP1 promoter and coordinates with HP1α, which is located at downstream CpG islands and recruits SUV39H1/H3K9me3/DNMTs to repress SFRP1 transcription

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BMC Cancer

ISSN: 1471-2407

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