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Fig. 5 | BMC Cancer

Fig. 5

From: The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells

Fig. 5

The effect of H2A.Z and/or SFRP1 silencing on the proliferation and invasion of ICC cells. HuccT-1 and RBE cells were transduced with LV-shRNA-NC (negative control), LV-shR-H2A.Z and/or siR-SFRP1 to generate cells with silencing. Proliferation, invasion and wound healing were evaluated. A The dynamic proliferation of ICC cells. B The result of nude mouse tumorigenicity assay, and the expression of PCNA in mouse tissues. C The invasion of ICC cells (200 × magnification). D The wound healing ability of ICC cells. The data shown are representative images or expressed as individual mean values or the means ± SDs of each group in three separate experiments. *p < 0.05, **p < 0.01, ***p < 0.001

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BMC Cancer

ISSN: 1471-2407

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