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Fig. 3 | BMC Cancer

Fig. 3

From: The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells

Fig. 3

H2A.Z forms a complex with KDM1A, H3K4me1 and H3K4me2. A Western blot analysis revealed that H2A.Z is mainly expressed in the nucleus in HuccT-1 and RBE cells. B Immunofluorescence (IF) analysis of the nuclear localization of H2A.Z in HuccT-1 and RBE cells (400 × magnification). C Western blot analysis revealed that H2A.Z is mainly expressed in the nucleus in HuccT-1 and RBE cells with H2A.Z silencing. E Endogenous KDM1A, H3K4me1 and H3K4me2 were precipitated with the anti-H2A.Z antibody in HuccT-1, RBE and HIBEpic cells. F Western blot analysis revealed that KDM1A silencing can increase the relative level of SFRP1 expression

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BMC Cancer

ISSN: 1471-2407

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