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Table 2 Univariate and Multivariate Cox proportional hazards analysis of various prognostic factors and their relationship to overall survival

From: The prognostic significance of the circumferential resection margin in esophageal squamous cell carcinoma patients without neoadjuvant treatment

 

Univariate

Multivariate (CAP)

Multivariate (RCP)

Multivariate (three-tier criteria)

Parameter

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Sex

Male/Female

0.983(0.783–1.233)

0.882

      

Age (years)

 ≤ 60/ > 60

1.285(1.069–1.545)

0.007

1.017(1.006–1.028)

0.002

1.018(1.007–1.029)

0.001

1.018(1.007–1.029)

0.001

Tumor location

Upper thoracic

1

       

Middle thoracic

0.995(0.756–1.312)

0.974

      

Lower thoracic

1.086(0.806–1.464)

0.586

      

Degree of differentiation

Well and Moderate/Poor

1.656(1.231–2.228)

0.001

1.353(1.000–1.832)

0.050

1.400(1.037–1.890)

0.028

1.357(1.003–1.836)

0.048

LVI

No/Yes

1.724(1.426–2.084)

 < 0.001

1.200(0.977–1.473)

0.082

1.206(0.983–1.479)

0.073

1.189(0.969–1.460)

0.098

PNI

No/Yes

1.500(1.233–1.825)

 < 0.001

1.226(1.001–1.502)

0.049

1.212(0.989–1.485)

0.064

1.211(0.988–1.484)

0.065

pN

N0

1

 

1

 

1

 

1

 

N1

1.783(1.420–2.237)

 < 0.001

1.697(1.338–2.151)

 < 0.001

1.625(1.282–2.060)

 < 0.001

1.673(1.319–2.123)

 < 0.001

N2

3.219(2.519–4.114)

 < 0.001

2.820(2.160–3.681)

 < 0.001

2.721(2.084–3.553)

 < 0.001

2.759(2.112–3.605)

 < 0.001

N3

4.536(3.248–6.334)

 < 0.001

3.727(2.615–5.311)

 < 0.001

3.756(2.632–5.361)

 < 0.001

3.694(2.590–5.268)

 < 0.001

CRM CAP criteria

R0/R1

2.107(1.543–2.877)

 < 0.001

1.814(1.321–2.492)

 < 0.001

    

CRM RCP criteria

R0/R1

1.517(1.260–1.826)

 < 0.001

  

1.295(1.072–1.564)

0.007

  

CRM three-tier criteria

 > 1 mm

1

     

1

 

0-1 mm

1.378(1.128–1.683)

0.002

    

1.185(0.968–1.452)

0.100

0 mm

2.350(1.706–3.238)

 < 0.001

    

1.933(1.394–2.680)

 < 0.001

Adjuvant therapy

No/Yes

1.467(1.205–1.785)

 < 0.001

1.072(0.869–1.323)

0.516

1.079(0.875–1.331)

0.478

1.073(0.870–1.324)

0.511

Extranodal invasiona

No/Yes

1.518(1.206–1.912)

 < 0.001

      
  1. CAP College of American Pathologists, CRM Circumferential resection margin, LVI Lymphovascular invasion, RCP Royal College of Pathologists, PNI Perineural invasion
  2. a This factor related to prognosis were not examined in the multivariate analysis