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Table 6 Summary of associations between selected biomarkers and outcomes of breast cancer prognosis

From: Associations between circulating obesity-related biomarkers and prognosis in female breast cancer survivors: a systematic review of observational data in women enrolled in lifestyle intervention trials

 

Testosterone

Estradiol/SHBG

Insulin/C-Peptide

HOMA-IR

HDL-c/TG

IGF-1/IGFBP-1,

IGFBP-3/PDGF

Adipokines (Adiponectin/Leptin)

CRP

Recurrence

↑ WHEL [25]

— Estradiol, SHBG

DIANA 2 [20]; WHEL [25]

— Insulin

DIANA 2 [20]

—DIANA 5 [23]

-- HDL-c, TG

DIANA 2 [21]

↓ HDL-c

DIANA 5 [23]

↑ TG

DIANA 5 [23]

— IGF-1, PDGF

DIANA 2 [22]

↑ IGF-1 + PDGF DIANA 2 [22]

N.A.

— DIANA 2 [22]

↑ DIANA 2 [20]

↑ T + MetSa

DIANA 2 [21]

↑ PACThe [24]

Disease-free survival

↓ PACThe [24]

N.A.

N.A.

N.A.

↑ HDL-c

PACThe [24]

N.A.

N.A.

N.A.

Breast cancer event

N.A.

N.A.

— Insulin

WHEL [26]

N.A.

N.A.

— IGF-1, IGFBP-3 WHEL [26]

—Adiponectin, Leptin

WHEL [26]

↑ WHEL [27]

Breast cancer mortality

N.A.

N.A.

N.A.

N.A.

N.A.

N.A.

N.A.

↑ WHEL [27]

All-cause mortality

N.A.

N.A.

N.A.

N.A.

N.A.

N.A.

N.A.

↑ WHEL [27]

  1. Abbreviations: CRP C-reactive protein, HDL-c High-density lipoprotein cholesterol, HOMA-IR Homeostatic model assessment for insulin resistance, IGF-1 Insulin-like growth factor-1, IGFBP-1 Insulin-like growth factor-binding protein 1, IGFBP-3 Insulin-like growth factor-binding protein 3, PDGF Platelet-derived growth factor, SHBG Sex hormone-binding globulin, TG Triglycerides
  2. ↑ significant positive association; ↓ significant negative association; —no significant association; N.A. not assessed
  3. a Women with metabolic syndrome and testosterone > 0.40 ng/mL