Outcomes | Non-adjusted Model | Model I | Model II | |||
---|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
Cancer Mortality No. of deaths/patients (342/3504) | ||||||
Dietary Niacin, 10 mg/day | 0.85 (0.77–0.95) | 0.003 | 0.83 (0.75–0.93) | 0.001 | 0.81 (0.67–0.98) | 0.032 |
Niacin classification | ||||||
Quartile 1 | Reference | Reference | Reference | |||
Quartile 2 | 0.71 (0.53–0.93) | 0.015 | 0.65 (0.49–0.86) | 0.003 | 0.60 (0.44–0.82) | 0.001 |
Quartile 3 | 0.56 (0.42–0.76) | < 0.001 | 0.52 (0.38–0.7) | < 0.001 | 0.49 (0.34–0.71) | < 0.001 |
Quartile 4 | 0.61 (0.46–0.82) | 0.001 | 0.57 (0.42–0.77) | < 0.001 | 0.51 (0.32–0.82) | 0.005 |
P for Trend | < 0.001 | < 0.001 | 0.001 | |||
All-Cause of Mortality No. of deaths/patients (1054/3504) | ||||||
Dietary Niacin, 10 mg/day | 0.88 (0.83–0.94) | < 0.001 | 0.87 (0.81–0.92) | < 0.001 | 0.89 (0.8–1.0) | 0.042 |
Niacin classification | ||||||
Quartile 1 | Reference | Reference | Reference | |||
Quartile 2 | 0.86 (0.73–1.01) | 0.067 | 0.81 (0.69–0.95) | 0.011 | 0.81 (0.67–0.97) | 0.021 |
Quartile 3 | 0.73 (0.61–0.86) | < 0.001 | 0.64 (0.54–0.76) | < 0.001 | 0.69 (0.55–0.85) | 0.001 |
Quartile 4 | 0.64 (0.54–0.77) | < 0.001 | 0.61 (0.51–0.73) | < 0.001 | 0.73 (0.55–0.97) | 0.027 |
P for Trend | < 0.001 | < 0.001 | 0.005 |