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Table 2 The relationship between dietary niacin intake and mortality among cancer patients, NHANES (1999–2014)

From: Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort

Outcomes

Non-adjusted Model

Model I

Model II

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

Cancer Mortality No. of deaths/patients (342/3504)

 Dietary Niacin, 10 mg/day

0.85 (0.77–0.95)

0.003

0.83 (0.75–0.93)

0.001

0.81 (0.67–0.98)

0.032

  Niacin classification

   Quartile 1

Reference

 

Reference

 

Reference

 

   Quartile 2

0.71 (0.53–0.93)

0.015

0.65 (0.49–0.86)

0.003

0.60 (0.44–0.82)

0.001

   Quartile 3

0.56 (0.42–0.76)

< 0.001

0.52 (0.38–0.7)

< 0.001

0.49 (0.34–0.71)

< 0.001

   Quartile 4

0.61 (0.46–0.82)

0.001

0.57 (0.42–0.77)

< 0.001

0.51 (0.32–0.82)

0.005

   P for Trend

 

< 0.001

 

< 0.001

 

0.001

All-Cause of Mortality No. of deaths/patients (1054/3504)

 Dietary Niacin, 10 mg/day

0.88 (0.83–0.94)

< 0.001

0.87 (0.81–0.92)

< 0.001

0.89 (0.8–1.0)

0.042

  Niacin classification

   Quartile 1

Reference

 

Reference

 

Reference

 

   Quartile 2

0.86 (0.73–1.01)

0.067

0.81 (0.69–0.95)

0.011

0.81 (0.67–0.97)

0.021

   Quartile 3

0.73 (0.61–0.86)

< 0.001

0.64 (0.54–0.76)

< 0.001

0.69 (0.55–0.85)

0.001

   Quartile 4

0.64 (0.54–0.77)

< 0.001

0.61 (0.51–0.73)

< 0.001

0.73 (0.55–0.97)

0.027

   P for Trend

 

< 0.001

 

< 0.001

 

0.005

  1. Model 1: Cox proportional hazards regression model stratified by age, sex, and race, bmi
  2. Model 2: Further adjusted for education, smoking status, drinking,diabetes, aspirin use, physical activity, energy intake, protein intake, sugar, carbohydrate, total fat intake, Vit B1, VitB2, Cholesterol, fiber
  3. Abbreviations: HR hazard ratio, BMI body mass index, CI confidence interval