Fig. 8
From: MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer
MAPK8IP2 is highly expressed in PCa cells and knockdown of MAPK8IP2 inhibited PC3, DU145, and 22RV1 cells proliferation, migration, and invasion. A qRT–PCR analysis showed high expression of MAPK8IP2 in PCa cells compared with normal prostate epithelial cell (HPrEC and RWPE1). B Western blot analysis demonstrated that MAPK8IP2 highly expressed in PC3, DU145, and 22RV1 cells compared with HPrEC cells. C, D qRT–PCR (C) and Western blot (D) detection of the MAPK8IP2 expression level after transfection with siNC and siMAPK8IP2. E, F EdU (E) and CCK-8 (F) assays revealed that knockdown of MAPK8IP2 suppressed PC3, DU145, and 22RV1 cells growth. G PC3, DU145, and 22RV1 cells migration and invasion abilities were assessed by transwell assays after downregulation of MAPK8IP2. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001