Fig. 7From: TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinomaProposed regulatory role of TWIST1 in promoting CSCs formation in ESCC. TWIST1 acts as a transcriptional regulator and triggers non-CSCs to reacquire CSC phenotypes through self-renewal and reprogramming processes (A), as well as through EMT (B)Back to article page