High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration

Table 1 Correlations between tumor HK2 expression and immune cell subsets

Immune cell subsets	Correlation coefficient^a	P value
Pan-immune cells (% of total cells)	0.030	0.855
CD3 + cells (% of ICs)	−0.283	0.077
CD4 + cells (% of CD3 + cells)	−0.225	0.162
CD4 + cells (% of ICs)	−0.326	0.040
CD8 + cells (% of CD3 + cells)	0.114	0.485
CD8 + cells (% of ICs)	−0.162	0.318
Treg (% of CD4 + cells)	0.480	0.003
Tregs (% of ICs)	0.239	0.161
CD8 + cells to Tregs ratio	−0.415	0.012
CD19 + cells (% of ICs)	−0.377	0.017
NK cells (% of ICs)	−0.134	0.411
Macrophages (% of ICs)	0.023	0.888
M0 (% of macrophages)	−0.116	0.477
M1 (% of macrophages)	0.089	0.584
M2 (% of macrophages)	−0.010	0.949
DCs (% of ICs)	0.091	0.604
MDSCs	0.028	0.901

Abbreviations: IC Immune cell, Tregs Regulatory T-cells, DC Dendritic cell, MDSC Myeloid-derived suppressor cell
^aSpearman correlation analysis

ISSN: 1471-2407