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Fig. 4 | BMC Cancer

Fig. 4

From: Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions

Fig. 4

The results of sensitivity analysis assuming that tumours may originate from a hierarchy of cells. a bar chart of the estimated \(R_{i}^{2}\) from the curve \(g(LCR_{i} ) = \gamma_{0i} + \gamma_{1i} LTCD_{{0}} + \varepsilon_{{{2}i}}\) in each EHlat i (\(i = 1, \cdots ,423\)) using global-wide ranked LCR matrix, representing the contributions of LTCD0 from the optimal EHlat (left) to the worst EHlat (right) to the variation of cancer risks; b bar chart of the estimated \(R_{i}^{2}\) from curve \(g(LCR_{i} ) = \lambda_{0i} + \lambda_{1i} SMN_{{0}} + \varepsilon_{{{3}i}}\) in each EHlat i (\(i = 1, \cdots ,423\)) using global-wide ranked LCR matrix, representing the contributions of SMN0 from the optimal EHlat (left) to the worst EHlat (right) to the variation of cancer risks. LTCD0: the error-prone value of the total number of tissue cell divisions per lifetime calculated in the laboratory environment; SMN0: the error-prone value of the somatic mutation number calculated in the laboratory environment; LCR: the observed lifetime cancer risk, EHlat: the level of EH (row) in the ranked LCR matrix

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