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Table 2 Univariate and multivariate analyses for DFS and OS in BC patients with PNI, SII, NLR and PLR

From: Prognostic significance of prognostic nutritional index and systemic immune‐inflammation index in patients after curative breast cancer resection: a retrospective cohort study

 

DFS

OS

HR

95% CI

P value

P trend

HR

95% CI

P value

P trend

Univariate analyses

 PNI

    

0.004

    

0.294

  T1

1.00

1.00

1.00

-

 

1.00

1.00

1.00

-

 

  T2

0.55

0.31

0.98

0.044

 

0.38

0.10

1.54

0.177

 

  T3

0.41

0.22

0.75

0.004

 

0.52

0.16

1.70

0.278

 

 SII

    

0.949

    

0.663

  T1

1.00

1.00

1.00

-

 

1.00

1.00

1.00

-

 

  T2

1.59

0.89

2.86

0.119

 

1.45

0.35

6.09

0.609

 

  T3

1.01

0.52

1.96

0.977

 

1.41

0.31

6.28

0.656

 

 NLR

    

0.316

    

0.931

  T1

1.00

1.00

1.00

-

 

1.00

1.00

1.00

-

 

  T2

1.09

0.59

2.00

0.794

 

1.21

0.32

4.51

0.777

 

  T3

1.35

0.75

2.45

0.318

 

1.06

0.27

4.24

0.933

 

 PLR

    

0.086

    

0.196

  T1

1.00

1.00

1.00

-

 

1.00

1.00

1.00

-

 

  T2

2.00

1.05

3.81

0.036

 

0.47

0.09

2.59

0.389

 

  T3

1.83

0.94

3.55

0.076

 

2.11

0.62

7.24

0.233

 

Multivariate analysesa

 PNI

    

0.002

    

0.399

  T1

1.00

1.00

1.00

-

 

1.00

1.00

1.00

-

 

  T2

0.49

0.26

0.91

0.024

 

0.46

0.11

2.02

0.304

 

  T3

0.37

0.19

0.70

0.002

 

0.54

0.14

2.05

0.369

 

 SII

    

0.629

    

0.686

  T1

1.00

1.00

1.00

-

 

1.00

1.00

1.00

-

 

  T2

1.67

0.90

3.08

0.101

 

1.09

0.23

5.06

0.917

 

  T3

0.80

0.39

1.65

0.548

 

1.40

0.27

7.18

0.684

 

 NLR

    

0.350

    

0.872

  T1

1.00

1.00

1.00

-

 

1.00

1.00

1.00

-

 

  T2

1.33

0.69

2.58

0.395

 

0.87

0.20

3.76

0.852

 

  T3

1.37

0.71

2.62

0.345

 

0.89

0.20

3.91

0.876

 

 PLR

    

0.074

    

0.208

  T1

1.00

1.00

1.00

-

 

1.00

1.00

1.00

-

 

  T2

2.40

1.19

4.81

0.014

 

0.23

0.03

2.15

0.200

 

  T3

1.98

0.95

4.10

0.067

 

2.32

0.63

8.55

0.207

 
  1. T1-T3, PNI were divided into 3 quartiles: ≤ 53.0, 53.0 ~ 57.5, > 57.5; SII were divided into 3 quartiles: ≤ 429.43, 429.43 ~ 665.24, > 665.24; NLR were divided into 3 quartiles: ≤ 1.71, 1.71 ~ 2.43, > 2.43; PLR were divided into 3 quartiles: ≤ 115.66, 115.66 ~ 150.65, > 150.65
  2. Abbreviations: DFS Disease-free survival, BC Breast cancer, HR Hazard ratio, CI Confident interval, PNI Prognostic nutritional index, SII Systemic immune‐inflammation index, NLR Neutrophil–lymphocyte ratio, PLR Platelet-lymphocyte ratio, T Tertile, P P for trend
  3. aMultivariate model is adjusted for age, surgical options, pathological diagnosis; lymph node metastasis; tumour size; status of ER; status of PR; clinical classification; chemotherapy; radiotherapy; endocrine therapy; targeted therapy; family history of breast cancer
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BMC Cancer

ISSN: 1471-2407

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