Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches

Table 4 The association of BMI with incidence of lung cancer overall and different histologic types based on the multivariable MR analysis, the HUNT Study, 1995–97 to 2017 (N = 54,511)

LC	Cases		Multivariable MR-IVW			Multivariable MR-Egger
			HR¹	95% CI	P for Q²	HR¹	95% CI	P for Q²	P for inter³
Overall	873		1.07	0.96 –1.19	0.51	1.16	0.98–1.38	0.55	0.23
SC	136		1.08	0.83–1.42	0.79	1.32	0.85–2.04	0.81	0.26
AD	289		1.28	1.03–1.58	0.01	1.45	1.01–2.06	0.01	0.39
		Outlier-corrected⁴	1.25	1.02–1.53	0.09	1.52	1.09–2.11	0.11	0.14
SQ	177		0.96	0.76–1.21	0.99	0.89	0.60–1.31	0.99	0.66

Abbreviations: AD adenocarcinoma, BMI body mass index, CI confidence interval, HR hazard ratio, HUNT The Trøndelag Health Study, IVW inverse variance weighted method, LC lung cancer, MR Mendelian randomization, SC small-cell lung cancer, SQ squamous cell lung cancer
¹Per 1 unit (kg/m²) increase in genetically determined BMI
²P value for Cochran’s Q test
³P value for intercept test of multivariable MR-Egger regression
⁴Results after excluding the outlier SNP (rs2121279) for adenocarcinoma

ISSN: 1471-2407