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Table 3 The association of BMI change from HUNT1 to HUNT2 with incidence of lung cancer overall and different histologic types, the HUNT Study (N = 44,393)

From: Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches

LC

BMI change in quartiles (kg/m2)

Cases

IR (per 1000 person-years)

Crude modela

Main modelb

Additional Modelc

Main Model after imputationd

    

HR

95% CI

HR

95% CI

HR

95% CI

HR

95% CI

Overall

1st (-21.3–0.5)

363

1.96

 

Reference

1.00

Reference

1.00

Reference

1.00

Reference

 

2nd (0.6–1.7)

215

1.08

0.63

0.53–0.74

0.78

0.66–0.93

0.78

0.66–0.93

0.80

0.67–0.95

 

3rd (1.8–3.1)

177

0.81

0.52

0.43–0.62

0.71

0.59–0.85

0.71

0.59–0.86

0.73

0.61–0.88

 

4th (3.2–18.6)

153

0.75

0.54

0.44–0.65

0.75

0.62–0.91

0.75

0.61–0.91

0.78

0.64–0.95

SC

1st (-21.3–0.5)

62

0.33

1.00

Reference

1.00

Reference

1.00

Reference

1.00

Reference

 

2nd (0.6–1.7)

20

0.10

0.33

0.20–0.55

0.44

0.26–0.73

0.45

0.27–0.74

0.45

0.27–0.75

 

3rd (1.8–3.1)

23

0.11

0.38

0.23–0.62

0.54

0.33–0.88

0.55

0.34–0.90

0.57

0.35–0.92

 

4th (3.2–18.6)

27

0.13

0.53

0.34–0.84

0.74

0.46–1.19

0.75

0.47–1.21

0.80

0.49–1.28

AD

1st (-21.3–0.5)

112

0.60

1.00

Reference

1.00

Reference

1.00

Reference

1.00

Reference

 

2nd (0.6–1.7)

63

0.32

0.57

0.42–0.78

0.68

0.49–0.92

0.67

0.49–0.91

0.69

0.50–0.94

 

3rd (1.8–3.1)

61

0.28

0.55

0.40–0.75

0.68

0.49–0.94

0.67

0.49–0.92

0.69

0.50–0.95

 

4th (3.2–18.6)

60

0.29

0.63

0.46–0.87

0.78

0.56–1.09

0.77

0.55–1.07

0.80

0.58–1.12

SQ

1st (-21.3–0.5)

62

0.33

1.00

Reference

1.00

Reference

1.00

Reference

1.00

Reference

 

2nd (0.6–1.7)

53

0.27

0.92

0.63–1.32

1.18

0.82–1.71

1.19

0.82–1.73

1.21

0.84–1.76

 

3rd (1.8–3.1)

47

0.22

0.82

0.56–1.21

1.24

0.84–1.83

1.26

0.85–1.85

1.29

0.88–1.91

 

4th (3.2–18.6)

21

0.10

0.44

0.27–0.73

0.77

0.46–1.28

0.78

0.47–1.30

0.82

0.49–1.37

  1. Tvc option of the stcox command in Stata was used to model the non-proportional hazards in the main, additional, and imputed models. Non-proportional hazards for LC overall: sex, smoking, and economic difficulties; for SC: smoking; for AD: sex, smoking, economic difficulties; for SQ: education
  2. Abbreviations: AD adenocarcinoma, BMI body mass index, CI confidence interval, HR hazard ratio, HUNT The Trøndelag Health Study, IR incidence rate, LC lung cancer, SC small cell lung cancer, SQ squamous cell lung cancer
  3. aAge was used as the time scale in the crude model
  4. bMain model adjusted for sex, smoking, passive smoking, leisure physical activity, total sitting time daily, education, economic difficulties, family history of cancer, and self-reported chronic obstructive pulmonary disease (COPD). Age was used as the time scale
  5. cAdjusted for covariables in the main model plus asthma, alcohol consumption, and occupational activity. Age was used as the time scale
  6. dMissing information in the covariates of the main model were imputed