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Table 2 Multivariable Cox proportional hazards models results on risk of developing anogenital warts or precancerous lesions

From: HPV vaccination leads to decrease of anogenital warts and precancerous lesions of the cervix uteri in young women with low vaccination rates: a retrospective cohort analysis

Covariables

Hazard ratio (95% confidence interval)

Anogenital warts

Precancerous lesions

Vaccinated and unvaccinated

Vaccination status

Not vaccinated

1 (reference)

1 (reference)

Partially vaccinated

0·34 (0·31 – 0.38)

0·81 (0·74 – 0·89)

Fully vaccinated

0·37 (0·34 – 0.40)

0·77 (0·71 – 0·84)

Place of residence

Smaller city/region

1 (reference)

1 (reference)

Larger city

1·36 (1·28 – 1·45)

1·38 (1·28 – 1·48)

Vaccinated only

Vaccination status

Partially vaccinated

1 (reference)

1 (reference)

Fully vaccinated

1·02 (0·90 – 1·16)

0·92 (0·82 – 1·04)

Place of residence

Smaller city/region

1 (reference)

1 (reference)

Larger city

1·39 (1·20 – 1·61)

1·54 (1·35 – 1·76)

Type of vaccine

Vaccinated with Cervarix®

1 (reference)

1 (reference)

Vaccinated with Gardasil®/Gardasil9®

0·35 (0·30 – 0·40)

0·99 (0·80 – 1·21)

Contraception prescription before vaccination

No

1 (reference)

1 (reference)

Yes

1·49 (1·25 – 1·79)

1·49 (1·27 – 1·75)

  1. Analysis population: outcome analysis; vaccinated and unvaccinated young Bavarian women (n = 433 346), and vaccinated only (n = 175 351); HRs adjusted for all variables shown for the respective analysis. Definitions: Partially vaccinated: one dose (age nine to 14), one or two doses (from age 15), or when the interval between the first and last dose was shorter than six months; Fully vaccinated: two doses at age nine to 14 years or three doses from age 15; Place of residence: 25 district-free larger cities in Bavaria versus districts including smaller cities and rural areas